Predictive Value of the GLIM Criteria in Chinese Community-Dwelling and Institutionalized Older Adults Aged 70 Years and Over

• Published in: The Journal of nutrition, health & aging health & aging, 2021-05, Vol.25 (5), p.645-652
• Main Authors: Yeung, Suey S. Y., Chan, J. H. Y., Chan, R. S. M., Sham, A., Ho, S. C., Woo, J.
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Aging; China - epidemiology; Female; Frailty; Geriatrics/Gerontology; Humans; Independent Living; Institutionalization; Leadership; Male; Malnutrition; Malnutrition - diagnosis; Malnutrition - epidemiology; Medicine; Medicine & Public Health; Mortality; Neurosciences; Nutrition; Older people; Primary Care Medicine; Prospective Studies; Quality of Life Research
• ISSN: 1279-7707; 1760-4788
• DOI: 10.1007/s12603-021-1610-x

Objectives The Global Leadership Initiative on Malnutrition (GLIM) has recently published criteria for classifying malnutrition. This study investigated the associations between malnutrition and adverse outcomes, and identified which component(s) of the GLIM criteria is/are risk factor(s) of adverse outcomes in Chinese older adults. Design A prospective cohort study of Chinese older adults in a healthy ageing study. Setting Participants’ place of residence. Participants Community-dwelling and institutionalized Chinese older adults aged ≥70 years living in Hong Kong. Measurements Malnutrition at baseline was classified according to selected GLIM criteria. Adverse outcomes including poor self-rated health, functional limitation (Barthel Index), falls, frailty (FRAIL scale), hospitalization and mortality were assessed after a 3-year follow-up. Associations between malnutrition and components of selected GLIM criteria (weight loss, low body mass index (BMI), low muscle mass and disease burden) and each adverse outcome were examined using adjusted binary logistic regression and Cox proportional hazards model. Odds ratio (OR) or hazard ratio (HR) and 95% confidence interval (CI) are presented. Results Data of 1576 community-dwelling (45.5% female, 78.1±6.5 years) and 427 institutionalized (69.6% female, 85.5±6.4 years) older adults were included at baseline. Among community-dwelling older adults, malnutrition was associated with frailty (n=899, OR: 2.44, 95% CI: 1.05–5.70) and mortality (n=1007, HR: 1.37, 95% CI: 1.12–1.66). No association was found for other outcomes. Among institutionalized older adults, malnutrition was not associated with any outcomes. Low BMI and low muscle mass were risk factors of frailty; while weight loss was a risk factor of mortality in community-dwelling older adults. Weight loss and disease burden were risk factors of mortality among institutionalized older adults. Conclusion The association between malnutrition and frailty and mortality was observed in community but not in institutional settings. Further studies are required to draw more definitive conclusions on the use of GLIM criteria in institutional settings.