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Quantitative improvement of lymph nodes visualization of breast cancer using 99mTc-nanocolloid SPECT/CT and updated reconstruction algorithm
This study aimed to evaluate the impact of attenuation and scatter correction on the contrast to noise ratio values of SPECT and SPECT/CT images in sentinel lymph nodes scintigraphy. In addition, the effect of using an iterative reconstruction algorithm with variable iterations number and fixed subs...
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| Published in: | Radiation and environmental biophysics 2021-08, Vol.60 (3), p.447-451 |
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| creator | Işıkcı, Nazenin Ipek Abuqbeitah, Mohammad |
| description | This study aimed to evaluate the impact of attenuation and scatter correction on the contrast to noise ratio values of SPECT and SPECT/CT images in sentinel lymph nodes scintigraphy. In addition, the effect of using an iterative reconstruction algorithm with variable iterations number and fixed subsets was also investigated. 35 patients with a total of 44 lymph nodes were recruited in the current study. SPECT/CT scans were performed 3–4 h following peri-tumoral
99m
Tc-nanocolloid injection (≈1 mCi) at four points. Two image types were generated including SPECT with attenuation and scatter correction (AC–SC) and SPECT without any correction (NoAC–NoSC). The acquired projections were repeatedly reconstructed with eight subsets and 10, 20, 30 and 40 iterations. Afterwards, the calculated contrast to noise ratio values were used to investigate the effect of number of iteration and to compare the image quality of SPECT/CT and SPECT only. The mean contrast to noise (CNR) values of SPECT/CT scans were found to be 19,737, 26,418, 34,282 and 31,187 at 10, 20, 30 and 40 iterations, respectively. Whereas, the mean CNR values in SPECT (NoAC–NoSC) were as low as 8506, 10,582, 13,791 and 12,143 at 10, 20, 30 and 40 iterations, respectively. The CNR values of both SPECT and SPECT/CT improved with increasing number of iterations up to 30 iterations and then slightly decreased after 30–40 iterations. Likewise, no significant difference was found between 10 and 20 iterations (
P
value
= 0.06) in SPECT/CT, while a statistically significant difference was observed between 10 iterations and both 30 and 40 iterations (
P
value
|
| doi_str_mv | 10.1007/s00411-021-00914-w |
| format | article |
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99m
Tc-nanocolloid injection (≈1 mCi) at four points. Two image types were generated including SPECT with attenuation and scatter correction (AC–SC) and SPECT without any correction (NoAC–NoSC). The acquired projections were repeatedly reconstructed with eight subsets and 10, 20, 30 and 40 iterations. Afterwards, the calculated contrast to noise ratio values were used to investigate the effect of number of iteration and to compare the image quality of SPECT/CT and SPECT only. The mean contrast to noise (CNR) values of SPECT/CT scans were found to be 19,737, 26,418, 34,282 and 31,187 at 10, 20, 30 and 40 iterations, respectively. Whereas, the mean CNR values in SPECT (NoAC–NoSC) were as low as 8506, 10,582, 13,791 and 12,143 at 10, 20, 30 and 40 iterations, respectively. The CNR values of both SPECT and SPECT/CT improved with increasing number of iterations up to 30 iterations and then slightly decreased after 30–40 iterations. Likewise, no significant difference was found between 10 and 20 iterations (
P
value
= 0.06) in SPECT/CT, while a statistically significant difference was observed between 10 iterations and both 30 and 40 iterations (
P
value
< 0.05). It is concluded that the attenuation and scatter correction in SPECT/CT optimized the CNR values up to threefold compared to SPECT alone. Thus, a considerable improvement in the CNR values and the image quality can be obtained by increasing the iterations number to peak of 30 iterations.</description><identifier>ISSN: 0301-634X</identifier><identifier>EISSN: 1432-2099</identifier><identifier>DOI: 10.1007/s00411-021-00914-w</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Algorithms ; Attenuation ; Biological and Medical Physics ; Biophysics ; Breast cancer ; Computed tomography ; Ecosystems ; Effects of Radiation/Radiation Protection ; Environmental Physics ; Image contrast ; Image quality ; Image reconstruction ; Lymph nodes ; Lymphatic system ; Medical imaging ; Monitoring/Environmental Analysis ; Noise ; Original Article ; Physics ; Physics and Astronomy ; Scattering ; Scintigraphy ; Single photon emission computed tomography ; Statistical analysis</subject><ispartof>Radiation and environmental biophysics, 2021-08, Vol.60 (3), p.447-451</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c197w-a12936fb4e8082e764e26bb904f57bbf864d992c4342ec1ad79646f2a48758f3</citedby><cites>FETCH-LOGICAL-c197w-a12936fb4e8082e764e26bb904f57bbf864d992c4342ec1ad79646f2a48758f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Işıkcı, Nazenin Ipek</creatorcontrib><creatorcontrib>Abuqbeitah, Mohammad</creatorcontrib><title>Quantitative improvement of lymph nodes visualization of breast cancer using 99mTc-nanocolloid SPECT/CT and updated reconstruction algorithm</title><title>Radiation and environmental biophysics</title><addtitle>Radiat Environ Biophys</addtitle><description>This study aimed to evaluate the impact of attenuation and scatter correction on the contrast to noise ratio values of SPECT and SPECT/CT images in sentinel lymph nodes scintigraphy. In addition, the effect of using an iterative reconstruction algorithm with variable iterations number and fixed subsets was also investigated. 35 patients with a total of 44 lymph nodes were recruited in the current study. SPECT/CT scans were performed 3–4 h following peri-tumoral
99m
Tc-nanocolloid injection (≈1 mCi) at four points. Two image types were generated including SPECT with attenuation and scatter correction (AC–SC) and SPECT without any correction (NoAC–NoSC). The acquired projections were repeatedly reconstructed with eight subsets and 10, 20, 30 and 40 iterations. Afterwards, the calculated contrast to noise ratio values were used to investigate the effect of number of iteration and to compare the image quality of SPECT/CT and SPECT only. The mean contrast to noise (CNR) values of SPECT/CT scans were found to be 19,737, 26,418, 34,282 and 31,187 at 10, 20, 30 and 40 iterations, respectively. Whereas, the mean CNR values in SPECT (NoAC–NoSC) were as low as 8506, 10,582, 13,791 and 12,143 at 10, 20, 30 and 40 iterations, respectively. The CNR values of both SPECT and SPECT/CT improved with increasing number of iterations up to 30 iterations and then slightly decreased after 30–40 iterations. Likewise, no significant difference was found between 10 and 20 iterations (
P
value
= 0.06) in SPECT/CT, while a statistically significant difference was observed between 10 iterations and both 30 and 40 iterations (
P
value
< 0.05). It is concluded that the attenuation and scatter correction in SPECT/CT optimized the CNR values up to threefold compared to SPECT alone. Thus, a considerable improvement in the CNR values and the image quality can be obtained by increasing the iterations number to peak of 30 iterations.</description><subject>Algorithms</subject><subject>Attenuation</subject><subject>Biological and Medical Physics</subject><subject>Biophysics</subject><subject>Breast cancer</subject><subject>Computed tomography</subject><subject>Ecosystems</subject><subject>Effects of Radiation/Radiation Protection</subject><subject>Environmental Physics</subject><subject>Image contrast</subject><subject>Image quality</subject><subject>Image reconstruction</subject><subject>Lymph nodes</subject><subject>Lymphatic system</subject><subject>Medical imaging</subject><subject>Monitoring/Environmental Analysis</subject><subject>Noise</subject><subject>Original Article</subject><subject>Physics</subject><subject>Physics and Astronomy</subject><subject>Scattering</subject><subject>Scintigraphy</subject><subject>Single photon emission computed tomography</subject><subject>Statistical analysis</subject><issn>0301-634X</issn><issn>1432-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kc1q3DAURkVIINM0L5CVoJtu3OjPsrUsQ5oWAm2oF9kJWb6eKNjSRJJnSJ8hD10lEyh0kYW4C53v414OQheUfKGENJeJEEFpRVh5RFFR7Y_QigrOKkaUOkYrwgmtJBd3p-hDSg-E0EZKtULPt4vx2WWT3Q6wm7cx7GAGn3EY8fQ0b--xDwMkvHNpMZP7U8DgXz77CCZlbI23EPGSnN9gpebOVt74YMM0BTfg37-u1t3lusPGD3jZDibDgCPY4FOOi30tM9MmRJfv54_oZDRTgvO3eYa6b1fd-nt18_P6x_rrTWWpavaVoUxxOfYCWtIyaKQAJvteETHWTd-PrRSDUswKLhhYaoZGSSFHZkTb1O3Iz9DnQ2059nGBlPXskoVpMh7CkjSrGeOqpYQW9NN_6ENYoi_LFaoWsuacq0KxA2VjSCnCqLfRzSY-aUr0ix998KOLH_3qR-9LiB9CqcB-A_Ff9Tupv4IIlZs</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Işıkcı, Nazenin Ipek</creator><creator>Abuqbeitah, Mohammad</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7ST</scope><scope>7TK</scope><scope>7TM</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>20210801</creationdate><title>Quantitative improvement of lymph nodes visualization of breast cancer using 99mTc-nanocolloid SPECT/CT and updated reconstruction algorithm</title><author>Işıkcı, Nazenin Ipek ; Abuqbeitah, Mohammad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c197w-a12936fb4e8082e764e26bb904f57bbf864d992c4342ec1ad79646f2a48758f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Algorithms</topic><topic>Attenuation</topic><topic>Biological and Medical Physics</topic><topic>Biophysics</topic><topic>Breast cancer</topic><topic>Computed tomography</topic><topic>Ecosystems</topic><topic>Effects of Radiation/Radiation Protection</topic><topic>Environmental Physics</topic><topic>Image contrast</topic><topic>Image quality</topic><topic>Image reconstruction</topic><topic>Lymph nodes</topic><topic>Lymphatic system</topic><topic>Medical imaging</topic><topic>Monitoring/Environmental Analysis</topic><topic>Noise</topic><topic>Original Article</topic><topic>Physics</topic><topic>Physics and Astronomy</topic><topic>Scattering</topic><topic>Scintigraphy</topic><topic>Single photon emission computed tomography</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Işıkcı, Nazenin Ipek</creatorcontrib><creatorcontrib>Abuqbeitah, Mohammad</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Radiation and environmental biophysics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Işıkcı, Nazenin Ipek</au><au>Abuqbeitah, Mohammad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative improvement of lymph nodes visualization of breast cancer using 99mTc-nanocolloid SPECT/CT and updated reconstruction algorithm</atitle><jtitle>Radiation and environmental biophysics</jtitle><stitle>Radiat Environ Biophys</stitle><date>2021-08-01</date><risdate>2021</risdate><volume>60</volume><issue>3</issue><spage>447</spage><epage>451</epage><pages>447-451</pages><issn>0301-634X</issn><eissn>1432-2099</eissn><abstract>This study aimed to evaluate the impact of attenuation and scatter correction on the contrast to noise ratio values of SPECT and SPECT/CT images in sentinel lymph nodes scintigraphy. In addition, the effect of using an iterative reconstruction algorithm with variable iterations number and fixed subsets was also investigated. 35 patients with a total of 44 lymph nodes were recruited in the current study. SPECT/CT scans were performed 3–4 h following peri-tumoral
99m
Tc-nanocolloid injection (≈1 mCi) at four points. Two image types were generated including SPECT with attenuation and scatter correction (AC–SC) and SPECT without any correction (NoAC–NoSC). The acquired projections were repeatedly reconstructed with eight subsets and 10, 20, 30 and 40 iterations. Afterwards, the calculated contrast to noise ratio values were used to investigate the effect of number of iteration and to compare the image quality of SPECT/CT and SPECT only. The mean contrast to noise (CNR) values of SPECT/CT scans were found to be 19,737, 26,418, 34,282 and 31,187 at 10, 20, 30 and 40 iterations, respectively. Whereas, the mean CNR values in SPECT (NoAC–NoSC) were as low as 8506, 10,582, 13,791 and 12,143 at 10, 20, 30 and 40 iterations, respectively. The CNR values of both SPECT and SPECT/CT improved with increasing number of iterations up to 30 iterations and then slightly decreased after 30–40 iterations. Likewise, no significant difference was found between 10 and 20 iterations (
P
value
= 0.06) in SPECT/CT, while a statistically significant difference was observed between 10 iterations and both 30 and 40 iterations (
P
value
< 0.05). It is concluded that the attenuation and scatter correction in SPECT/CT optimized the CNR values up to threefold compared to SPECT alone. Thus, a considerable improvement in the CNR values and the image quality can be obtained by increasing the iterations number to peak of 30 iterations.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00411-021-00914-w</doi><tpages>5</tpages></addata></record> |
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| subjects | Algorithms Attenuation Biological and Medical Physics Biophysics Breast cancer Computed tomography Ecosystems Effects of Radiation/Radiation Protection Environmental Physics Image contrast Image quality Image reconstruction Lymph nodes Lymphatic system Medical imaging Monitoring/Environmental Analysis Noise Original Article Physics Physics and Astronomy Scattering Scintigraphy Single photon emission computed tomography Statistical analysis |
| title | Quantitative improvement of lymph nodes visualization of breast cancer using 99mTc-nanocolloid SPECT/CT and updated reconstruction algorithm |
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