Association Between Portal Vein Thrombosis and Pouchitis in Patients with Ulcerative Colitis

Background Pouchitis is the most common long-term complication in patients requiring colectomy ileal pouch-anal anastomosis with medically refractory ulcerative colitis or colitis-associated neoplasia. A previous small case series suggests associated between portal vein thrombosis (PVT) and ischemic...

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Bibliographic Details
Published in:Digestive diseases and sciences 2022-04, Vol.67 (4), p.1303-1310
Main Authors: Syed, Aslam, Seoud, Talal, Carleton, Neil M., Thakkar, Shyam, Kiran, Ravi P., Shen, Bo
Format: Article
Language:English
Subjects:
Antibiotics
Biochemistry
Blood clot
Care and treatment
Colitis, Ulcerative - complications
Colitis, Ulcerative - surgery
Colonic Pouches - adverse effects
Comparative analysis
Complications and side effects
Construction
Gastroenterology
Gender
Hepatology
Humans
Inflammatory bowel disease
Male
Medical colleges
Medical records
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Oncology
Original Article
Patients
Population
Portal Vein - surgery
Postoperative Complications - etiology
Pouchitis - epidemiology
Pouchitis - etiology
Proctocolectomy, Restorative - adverse effects
Risk factors
Statistical analysis
Thrombosis
Transplant Surgery
Ulcerative colitis
Venous Thrombosis - complications
Venous Thrombosis - etiology
White people
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Summary:Background Pouchitis is the most common long-term complication in patients requiring colectomy ileal pouch-anal anastomosis with medically refractory ulcerative colitis or colitis-associated neoplasia. A previous small case series suggests associated between portal vein thrombosis (PVT) and ischemic pouchitis. Aim To evaluate the association between PVT and other demographic and clinical factors and pouchitis. Methods We used Explorys Inc., a population-based database, to search medical records between 1999 and 2020 with SNOMED-CT code criteria for “construction of pouch” and “ileal pouchitis.” Patients with pouchitis were compared to those with previous pouch construction without pouchitis. Factors associated with pouchitis identified with univariable analysis were introduced into a multivariable model. A post hoc analysis further stratified demographical findings of the association between PVT and pouchitis. Results We identified 7900 patients with ileal pouchitis (7.5%) and 97,510 with pouch construction without pouchitis. In multivariate binary logistic regression, adjusted odds ratio (aOR) for the risk of pouchitis in patients with PVT was 10.78 (95% confidence interval [CI] 7.04–16.49, P  
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-021-06969-5