Loading…

Genetically determined variations of selenoprotein P are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statins

Several single nucleotide polymorphisms (SNPs) could indirectly, as well directly, influence metabolic parameters related to health effects in response to selenium (Se) supplementation. This study aimed to investigate whether the selenoprotein SNPs were associated with the response of Se status biom...

Full description

Saved in:
Bibliographic Details
Published in:British journal of nutrition 2022-03, Vol.127 (5), p.679-686
Main Authors: Moriguchi Watanabe, Lígia, Bueno, Ana C., de Lima, Livia F., Ferraz-Bannitz, Rafael, Dessordi, Renata, Guimarães, Mariana P., Foss-Freitas, Maria C., Barbosa, Fernando, Navarro, Anderson M.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c416t-a580dae67864c646f2fdfd1d010310cfcfcd548fd6b3e4a4a390c22017c1c4033
cites cdi_FETCH-LOGICAL-c416t-a580dae67864c646f2fdfd1d010310cfcfcd548fd6b3e4a4a390c22017c1c4033
container_end_page 686
container_issue 5
container_start_page 679
container_title British journal of nutrition
container_volume 127
creator Moriguchi Watanabe, Lígia
Bueno, Ana C.
de Lima, Livia F.
Ferraz-Bannitz, Rafael
Dessordi, Renata
Guimarães, Mariana P.
Foss-Freitas, Maria C.
Barbosa, Fernando
Navarro, Anderson M.
description Several single nucleotide polymorphisms (SNPs) could indirectly, as well directly, influence metabolic parameters related to health effects in response to selenium (Se) supplementation. This study aimed to investigate whether the selenoprotein SNPs were associated with the response of Se status biomarkers to the Brazil nut consumption in patients using statins and if the variation in Se homoeostasis could affect antioxidant protection, lipid profile, muscle homoeostasis and selenoproteins mRNA. The study was performed in the Ribeirão Preto Medical School University Hospital. Thirty-two patients using statins received one unit of Brazil nut daily for 3 months. Body composition, blood Se concentrations, erythrocyte glutathione peroxidase (GPX) activity, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triacylglycerol (TAG), creatine kinase (CK) activity and gene expression of GPX1 and selenoprotein P (SELENOP) were evaluated before and after Brazil nut consumption. The volunteers were genotyped for SNP in GPX1 (rs1050450) and SELENOP (rs3877899 and rs7579). SNPs in selenoproteins were not associated with plasma and erythrocyte Se, but SNPs in SELENOP influenced the response of erythrocyte GPX activity and CK activity, TAG and LDL after Brazil nut consumption. Also, Brazil nut consumption increased GPX1 mRNA expression only in subjects with rs1050450 CC genotype. SELENOP mRNA expression was significantly lower in subjects with rs7579 GG genotype before and after the intervention. Thus, SNP in SELENOP could be associated with interindividual differences in Se homeostasis after Brazil nut consumption, emphasising the involvement of genetic variability in response to Se consumption towards health maintenance and disease prevention.
doi_str_mv 10.1017/S000711452100146X
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2522398499</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1017_S000711452100146X</cupid><sourcerecordid>2632939106</sourcerecordid><originalsourceid>FETCH-LOGICAL-c416t-a580dae67864c646f2fdfd1d010310cfcfcd548fd6b3e4a4a390c22017c1c4033</originalsourceid><addsrcrecordid>eNp1kc2O1DAMxysEYoeFB-CCLHHhsIV8NW2PsGIXpJVAAiRuVSZxlyxtUpIUdnguHhCPdgAJhHKwbP_8t2NX1UPOnnLG22fvGGMt56oRnDGu9Mdb1YartqmF1uJ2tdmn633-qLqX8xW5HWf93epIyl61qms31Y9zDFi8NdO0A4cF0-wDOvhqkjfFx5AhjpBxwhCXFAv6AG_BJASTc7TEEPzNl09gAuHX3pE9gXnNdp1MOqGwg8kv3sHWx9mkz5gykEjCvJA6QonwIpnvfoKwFrAUW-dl3xm2O1hoBgwlw5p9uIRcyA_5fnVnNFPGBwd7XH04e_n-9FV98eb89enzi9oqrkttmo45g7rttLJa6VGMbnTcMc4kZ3ak5xrVjU5vJSqjjOyZFYI2a7lVTMrj6smNLv38y4q5DLPPFqfJBIxrHkQjhOw71feEPv4LvYprCjTdILQUvew500TxG8qmmHPCcViSp6XsBs6G_UmHf05KNY8Oyut2Rve74tcNCZAHUTNvk3eX-Kf3_2V_AmGMr8s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2632939106</pqid></control><display><type>article</type><title>Genetically determined variations of selenoprotein P are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statins</title><source>Cambridge University Press</source><source>Free Full-Text Journals in Chemistry</source><creator>Moriguchi Watanabe, Lígia ; Bueno, Ana C. ; de Lima, Livia F. ; Ferraz-Bannitz, Rafael ; Dessordi, Renata ; Guimarães, Mariana P. ; Foss-Freitas, Maria C. ; Barbosa, Fernando ; Navarro, Anderson M.</creator><creatorcontrib>Moriguchi Watanabe, Lígia ; Bueno, Ana C. ; de Lima, Livia F. ; Ferraz-Bannitz, Rafael ; Dessordi, Renata ; Guimarães, Mariana P. ; Foss-Freitas, Maria C. ; Barbosa, Fernando ; Navarro, Anderson M.</creatorcontrib><description>Several single nucleotide polymorphisms (SNPs) could indirectly, as well directly, influence metabolic parameters related to health effects in response to selenium (Se) supplementation. This study aimed to investigate whether the selenoprotein SNPs were associated with the response of Se status biomarkers to the Brazil nut consumption in patients using statins and if the variation in Se homoeostasis could affect antioxidant protection, lipid profile, muscle homoeostasis and selenoproteins mRNA. The study was performed in the Ribeirão Preto Medical School University Hospital. Thirty-two patients using statins received one unit of Brazil nut daily for 3 months. Body composition, blood Se concentrations, erythrocyte glutathione peroxidase (GPX) activity, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triacylglycerol (TAG), creatine kinase (CK) activity and gene expression of GPX1 and selenoprotein P (SELENOP) were evaluated before and after Brazil nut consumption. The volunteers were genotyped for SNP in GPX1 (rs1050450) and SELENOP (rs3877899 and rs7579). SNPs in selenoproteins were not associated with plasma and erythrocyte Se, but SNPs in SELENOP influenced the response of erythrocyte GPX activity and CK activity, TAG and LDL after Brazil nut consumption. Also, Brazil nut consumption increased GPX1 mRNA expression only in subjects with rs1050450 CC genotype. SELENOP mRNA expression was significantly lower in subjects with rs7579 GG genotype before and after the intervention. Thus, SNP in SELENOP could be associated with interindividual differences in Se homeostasis after Brazil nut consumption, emphasising the involvement of genetic variability in response to Se consumption towards health maintenance and disease prevention.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S000711452100146X</identifier><identifier>PMID: 33947487</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Antioxidants ; Bertholletia ; Biomarkers ; Body composition ; Cholesterol ; Consumption ; Creatine ; Creatine kinase ; Density ; Dietary supplements ; Enzymes ; Erythrocytes ; Food ; Gene expression ; Genetic variability ; Glutathione ; Glutathione peroxidase ; Glutathione Peroxidase - metabolism ; High density lipoprotein ; Homeostasis ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Kinases ; Laboratories ; Lipids ; Low density lipoprotein ; Metabolism ; Metabolism and Metabolic Studies ; Muscles ; Nucleotides ; Nuts ; Oxidative stress ; Patients ; Peroxidase ; Plasma ; RNA, Messenger - genetics ; Selenium ; Selenoprotein P - genetics ; Selenoproteins ; Selenoproteins - genetics ; Single-nucleotide polymorphism ; Statins ; Supplements ; Triglycerides</subject><ispartof>British journal of nutrition, 2022-03, Vol.127 (5), p.679-686</ispartof><rights>The Author(s), 2021. Published by Cambridge University Press on behalf of The Nutrition Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-a580dae67864c646f2fdfd1d010310cfcfcd548fd6b3e4a4a390c22017c1c4033</citedby><cites>FETCH-LOGICAL-c416t-a580dae67864c646f2fdfd1d010310cfcfcd548fd6b3e4a4a390c22017c1c4033</cites><orcidid>0000-0001-7498-6165 ; 0000-0002-5916-569X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S000711452100146X/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,72960</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33947487$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moriguchi Watanabe, Lígia</creatorcontrib><creatorcontrib>Bueno, Ana C.</creatorcontrib><creatorcontrib>de Lima, Livia F.</creatorcontrib><creatorcontrib>Ferraz-Bannitz, Rafael</creatorcontrib><creatorcontrib>Dessordi, Renata</creatorcontrib><creatorcontrib>Guimarães, Mariana P.</creatorcontrib><creatorcontrib>Foss-Freitas, Maria C.</creatorcontrib><creatorcontrib>Barbosa, Fernando</creatorcontrib><creatorcontrib>Navarro, Anderson M.</creatorcontrib><title>Genetically determined variations of selenoprotein P are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statins</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Several single nucleotide polymorphisms (SNPs) could indirectly, as well directly, influence metabolic parameters related to health effects in response to selenium (Se) supplementation. This study aimed to investigate whether the selenoprotein SNPs were associated with the response of Se status biomarkers to the Brazil nut consumption in patients using statins and if the variation in Se homoeostasis could affect antioxidant protection, lipid profile, muscle homoeostasis and selenoproteins mRNA. The study was performed in the Ribeirão Preto Medical School University Hospital. Thirty-two patients using statins received one unit of Brazil nut daily for 3 months. Body composition, blood Se concentrations, erythrocyte glutathione peroxidase (GPX) activity, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triacylglycerol (TAG), creatine kinase (CK) activity and gene expression of GPX1 and selenoprotein P (SELENOP) were evaluated before and after Brazil nut consumption. The volunteers were genotyped for SNP in GPX1 (rs1050450) and SELENOP (rs3877899 and rs7579). SNPs in selenoproteins were not associated with plasma and erythrocyte Se, but SNPs in SELENOP influenced the response of erythrocyte GPX activity and CK activity, TAG and LDL after Brazil nut consumption. Also, Brazil nut consumption increased GPX1 mRNA expression only in subjects with rs1050450 CC genotype. SELENOP mRNA expression was significantly lower in subjects with rs7579 GG genotype before and after the intervention. Thus, SNP in SELENOP could be associated with interindividual differences in Se homeostasis after Brazil nut consumption, emphasising the involvement of genetic variability in response to Se consumption towards health maintenance and disease prevention.</description><subject>Antioxidants</subject><subject>Bertholletia</subject><subject>Biomarkers</subject><subject>Body composition</subject><subject>Cholesterol</subject><subject>Consumption</subject><subject>Creatine</subject><subject>Creatine kinase</subject><subject>Density</subject><subject>Dietary supplements</subject><subject>Enzymes</subject><subject>Erythrocytes</subject><subject>Food</subject><subject>Gene expression</subject><subject>Genetic variability</subject><subject>Glutathione</subject><subject>Glutathione peroxidase</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>High density lipoprotein</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</subject><subject>Kinases</subject><subject>Laboratories</subject><subject>Lipids</subject><subject>Low density lipoprotein</subject><subject>Metabolism</subject><subject>Metabolism and Metabolic Studies</subject><subject>Muscles</subject><subject>Nucleotides</subject><subject>Nuts</subject><subject>Oxidative stress</subject><subject>Patients</subject><subject>Peroxidase</subject><subject>Plasma</subject><subject>RNA, Messenger - genetics</subject><subject>Selenium</subject><subject>Selenoprotein P - genetics</subject><subject>Selenoproteins</subject><subject>Selenoproteins - genetics</subject><subject>Single-nucleotide polymorphism</subject><subject>Statins</subject><subject>Supplements</subject><subject>Triglycerides</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kc2O1DAMxysEYoeFB-CCLHHhsIV8NW2PsGIXpJVAAiRuVSZxlyxtUpIUdnguHhCPdgAJhHKwbP_8t2NX1UPOnnLG22fvGGMt56oRnDGu9Mdb1YartqmF1uJ2tdmn633-qLqX8xW5HWf93epIyl61qms31Y9zDFi8NdO0A4cF0-wDOvhqkjfFx5AhjpBxwhCXFAv6AG_BJASTc7TEEPzNl09gAuHX3pE9gXnNdp1MOqGwg8kv3sHWx9mkz5gykEjCvJA6QonwIpnvfoKwFrAUW-dl3xm2O1hoBgwlw5p9uIRcyA_5fnVnNFPGBwd7XH04e_n-9FV98eb89enzi9oqrkttmo45g7rttLJa6VGMbnTcMc4kZ3ak5xrVjU5vJSqjjOyZFYI2a7lVTMrj6smNLv38y4q5DLPPFqfJBIxrHkQjhOw71feEPv4LvYprCjTdILQUvew500TxG8qmmHPCcViSp6XsBs6G_UmHf05KNY8Oyut2Rve74tcNCZAHUTNvk3eX-Kf3_2V_AmGMr8s</recordid><startdate>20220314</startdate><enddate>20220314</enddate><creator>Moriguchi Watanabe, Lígia</creator><creator>Bueno, Ana C.</creator><creator>de Lima, Livia F.</creator><creator>Ferraz-Bannitz, Rafael</creator><creator>Dessordi, Renata</creator><creator>Guimarães, Mariana P.</creator><creator>Foss-Freitas, Maria C.</creator><creator>Barbosa, Fernando</creator><creator>Navarro, Anderson M.</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7498-6165</orcidid><orcidid>https://orcid.org/0000-0002-5916-569X</orcidid></search><sort><creationdate>20220314</creationdate><title>Genetically determined variations of selenoprotein P are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statins</title><author>Moriguchi Watanabe, Lígia ; Bueno, Ana C. ; de Lima, Livia F. ; Ferraz-Bannitz, Rafael ; Dessordi, Renata ; Guimarães, Mariana P. ; Foss-Freitas, Maria C. ; Barbosa, Fernando ; Navarro, Anderson M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-a580dae67864c646f2fdfd1d010310cfcfcd548fd6b3e4a4a390c22017c1c4033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antioxidants</topic><topic>Bertholletia</topic><topic>Biomarkers</topic><topic>Body composition</topic><topic>Cholesterol</topic><topic>Consumption</topic><topic>Creatine</topic><topic>Creatine kinase</topic><topic>Density</topic><topic>Dietary supplements</topic><topic>Enzymes</topic><topic>Erythrocytes</topic><topic>Food</topic><topic>Gene expression</topic><topic>Genetic variability</topic><topic>Glutathione</topic><topic>Glutathione peroxidase</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>High density lipoprotein</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</topic><topic>Kinases</topic><topic>Laboratories</topic><topic>Lipids</topic><topic>Low density lipoprotein</topic><topic>Metabolism</topic><topic>Metabolism and Metabolic Studies</topic><topic>Muscles</topic><topic>Nucleotides</topic><topic>Nuts</topic><topic>Oxidative stress</topic><topic>Patients</topic><topic>Peroxidase</topic><topic>Plasma</topic><topic>RNA, Messenger - genetics</topic><topic>Selenium</topic><topic>Selenoprotein P - genetics</topic><topic>Selenoproteins</topic><topic>Selenoproteins - genetics</topic><topic>Single-nucleotide polymorphism</topic><topic>Statins</topic><topic>Supplements</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moriguchi Watanabe, Lígia</creatorcontrib><creatorcontrib>Bueno, Ana C.</creatorcontrib><creatorcontrib>de Lima, Livia F.</creatorcontrib><creatorcontrib>Ferraz-Bannitz, Rafael</creatorcontrib><creatorcontrib>Dessordi, Renata</creatorcontrib><creatorcontrib>Guimarães, Mariana P.</creatorcontrib><creatorcontrib>Foss-Freitas, Maria C.</creatorcontrib><creatorcontrib>Barbosa, Fernando</creatorcontrib><creatorcontrib>Navarro, Anderson M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection (ProQuest Medical &amp; Health Databases)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database (ProQuest Medical &amp; Health Databases)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moriguchi Watanabe, Lígia</au><au>Bueno, Ana C.</au><au>de Lima, Livia F.</au><au>Ferraz-Bannitz, Rafael</au><au>Dessordi, Renata</au><au>Guimarães, Mariana P.</au><au>Foss-Freitas, Maria C.</au><au>Barbosa, Fernando</au><au>Navarro, Anderson M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetically determined variations of selenoprotein P are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statins</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2022-03-14</date><risdate>2022</risdate><volume>127</volume><issue>5</issue><spage>679</spage><epage>686</epage><pages>679-686</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><abstract>Several single nucleotide polymorphisms (SNPs) could indirectly, as well directly, influence metabolic parameters related to health effects in response to selenium (Se) supplementation. This study aimed to investigate whether the selenoprotein SNPs were associated with the response of Se status biomarkers to the Brazil nut consumption in patients using statins and if the variation in Se homoeostasis could affect antioxidant protection, lipid profile, muscle homoeostasis and selenoproteins mRNA. The study was performed in the Ribeirão Preto Medical School University Hospital. Thirty-two patients using statins received one unit of Brazil nut daily for 3 months. Body composition, blood Se concentrations, erythrocyte glutathione peroxidase (GPX) activity, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triacylglycerol (TAG), creatine kinase (CK) activity and gene expression of GPX1 and selenoprotein P (SELENOP) were evaluated before and after Brazil nut consumption. The volunteers were genotyped for SNP in GPX1 (rs1050450) and SELENOP (rs3877899 and rs7579). SNPs in selenoproteins were not associated with plasma and erythrocyte Se, but SNPs in SELENOP influenced the response of erythrocyte GPX activity and CK activity, TAG and LDL after Brazil nut consumption. Also, Brazil nut consumption increased GPX1 mRNA expression only in subjects with rs1050450 CC genotype. SELENOP mRNA expression was significantly lower in subjects with rs7579 GG genotype before and after the intervention. Thus, SNP in SELENOP could be associated with interindividual differences in Se homeostasis after Brazil nut consumption, emphasising the involvement of genetic variability in response to Se consumption towards health maintenance and disease prevention.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>33947487</pmid><doi>10.1017/S000711452100146X</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7498-6165</orcidid><orcidid>https://orcid.org/0000-0002-5916-569X</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0007-1145
ispartof British journal of nutrition, 2022-03, Vol.127 (5), p.679-686
issn 0007-1145
1475-2662
language eng
recordid cdi_proquest_miscellaneous_2522398499
source Cambridge University Press; Free Full-Text Journals in Chemistry
subjects Antioxidants
Bertholletia
Biomarkers
Body composition
Cholesterol
Consumption
Creatine
Creatine kinase
Density
Dietary supplements
Enzymes
Erythrocytes
Food
Gene expression
Genetic variability
Glutathione
Glutathione peroxidase
Glutathione Peroxidase - metabolism
High density lipoprotein
Homeostasis
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Kinases
Laboratories
Lipids
Low density lipoprotein
Metabolism
Metabolism and Metabolic Studies
Muscles
Nucleotides
Nuts
Oxidative stress
Patients
Peroxidase
Plasma
RNA, Messenger - genetics
Selenium
Selenoprotein P - genetics
Selenoproteins
Selenoproteins - genetics
Single-nucleotide polymorphism
Statins
Supplements
Triglycerides
title Genetically determined variations of selenoprotein P are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statins
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T11%3A04%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetically%20determined%20variations%20of%20selenoprotein%20P%20are%20associated%20with%20antioxidant,%20muscular,%20and%20lipid%20biomarkers%20in%20response%20to%20Brazil%20nut%20consumption%20by%20patients%20using%20statins&rft.jtitle=British%20journal%20of%20nutrition&rft.au=Moriguchi%20Watanabe,%20L%C3%ADgia&rft.date=2022-03-14&rft.volume=127&rft.issue=5&rft.spage=679&rft.epage=686&rft.pages=679-686&rft.issn=0007-1145&rft.eissn=1475-2662&rft_id=info:doi/10.1017/S000711452100146X&rft_dat=%3Cproquest_cross%3E2632939106%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c416t-a580dae67864c646f2fdfd1d010310cfcfcd548fd6b3e4a4a390c22017c1c4033%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2632939106&rft_id=info:pmid/33947487&rft_cupid=10_1017_S000711452100146X&rfr_iscdi=true