Impact of optimal heart rate on left ventricular reverse remodeling and functional improvement in patients with systolic heart failure

Heart rate modulation therapy using ivabradine reduces mortality and morbidity in patients with systolic heart failure, whereas too reduced heart rate seems to worsen the clinical outcome. The optimal heart rate during heart rate modulation therapy remains unknown. Consecutive patients with left ven...

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Bibliographic Details
Published in:Heart and vessels 2021-11, Vol.36 (11), p.1688-1693
Main Authors: Izumida, Toshihide, Imamura, Teruhiko, Ueno, Yohei, Tanaka, Shuhei, Kataoka, Naoya, Nakamura, Makiko, Kinugawa, Koichiro
Format: Article
Language:English
Subjects:
Aged
Biomedical Engineering and Bioengineering
Brain natriuretic peptide
Cardiac Surgery
Cardiology
Congestive heart failure
Deceleration
Diameters
Ejection fraction
Heart failure
Heart Failure - drug therapy
Heart Failure, Systolic - diagnosis
Heart Failure, Systolic - drug therapy
Heart Rate
Humans
Male
Mathematical analysis
Medicine
Medicine & Public Health
Modulation
Morbidity
Optimization
Original Article
Patients
Prospective Studies
Retrospective Studies
Stroke Volume
Vascular Surgery
Ventricle
Ventricular Function, Left - physiology
Ventricular Remodeling - physiology
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Summary:Heart rate modulation therapy using ivabradine reduces mortality and morbidity in patients with systolic heart failure, whereas too reduced heart rate seems to worsen the clinical outcome. The optimal heart rate during heart rate modulation therapy remains unknown. Consecutive patients with left ventricular ejection fraction 
ISSN:0910-8327
1615-2573
DOI:10.1007/s00380-021-01864-5