Hydration and glycogen affect T1 relaxation times of liver tissue

T1 mapping is a useful tool for the assessment of patients with nonalcoholic fatty liver disease but still suffers from a large unexplained variance in healthy subjects. This study aims to characterize the potential effects of liver glycogen concentration and body hydration status on liver shortened...

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Bibliographic Details
Published in:NMR in biomedicine 2021-07, Vol.34 (7), p.e4530-n/a
Main Authors: Mózes, Ferenc E., Valkovič, Ladislav, Pavlides, Michael, Robson, Matthew D., Tunnicliffe, Elizabeth M.
Format: Article
Language:English
Subjects:
Aorta
Biological products
Fasting
Fatty liver
Glycogen
Glycogens
Hydration
Inversion
Liver
Liver diseases
Magnetic resonance imaging
Mapping
Mean
Proton density (concentration)
Recovery
Rehydration
shMOLLI T1
Spectroscopy
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Summary:T1 mapping is a useful tool for the assessment of patients with nonalcoholic fatty liver disease but still suffers from a large unexplained variance in healthy subjects. This study aims to characterize the potential effects of liver glycogen concentration and body hydration status on liver shortened modified Look‐Locker inversion recovery (shMOLLI) T1 measurements. Eleven glycogen phantoms and 12 healthy volunteers (mean age: 31 years, three females) were scanned at 3 T using inversion recovery spin echo, multiple contrast spin echo (in phantoms), shMOLLI T1 mapping, multiple‐echo spoiled gradient recalled echo and 13C spectroscopy (in healthy volunteers). Phantom r1 and r2 relaxivities were determined from measured T1 and T2 values. Participants underwent a series of five metabolic experiments to vary their glycogen concentration and hydration levels: feeding, food fasting, exercising, underhydration, and rehydration. Descriptive statistics were calculated for shMOLLI T1, inferior vena cava to aorta cross‐sectional area ratio (IVC/Ao) as a marker of body hydration status, glycogen concentration, T2* and proton density fat fraction values. A linear mixed model for shMOLLI R1 was constructed to determine the effects of glycogen concentration and IVC/Ao ratio. The mean shMOLLI T1 after fasting was 737 ± 67 ms. The mean within‐subject change was 80 ± 45 ms. The linear mixed model revealed a glycogen r1 relaxivity in volunteers (0.18 M−1 s−1, p = 0.03) close to that determined in phantoms (0.28 M−1 s−1). A unit change in IVC/Ao ratio was associated with a drop of −0.113 s−1 in R1 (p 
ISSN:0952-3480
1099-1492
DOI:10.1002/nbm.4530