Acute Effects of Frequent Light-Intensity Standing-Based Exercises That Interrupt 8 Hours of Prolonged Sitting on Postprandial Glucose in Stroke Survivors: A Dose-Escalation Trial

• Published in: Journal of physical activity & health 2021-06, Vol.18 (6), p.644-652
• Main Authors: Mackie, Paul, Crowfoot, Gary, Gyawali, Prajwal, Janssen, Heidi, Holliday, Elizabeth, Dunstan, David, English, Coralie
• Format: Article
• Language: English
• Subjects: Adult; Blood Glucose; Confidence intervals; Cross-Over Studies; Exercise; Glucose; Humans; Insulin; Postprandial Period; Posture; Stroke; Survivors; Walking
• ISSN: 1543-3080; 1543-5474
• DOI: 10.1123/jpah.2020-0516

Interrupting prolonged sitting can attenuate postprandial glucose responses in overweight adults. The dose-response effect in stroke survivors is unknown. The authors investigated the effects of interrupting 8 hours of prolonged sitting with increasingly frequent bouts of light-intensity standing-based exercises on the postprandial glucose response in stroke survivors. Within-participant, laboratory-based, dose-escalation trial. Participants completed three 8-hour conditions: prolonged sitting and 2 experimental conditions. Experimental conditions involved light-intensity standing-based exercises of increasing frequency (2 × 5 min to 6 × 5 min bouts). Postprandial glucose is reported. Twenty-nine stroke survivors (aged 66 y) participated. Interrupting 8 hours of prolonged sitting with light-intensity standing-based exercises every 90 minutes significantly decreased postprandial glucose (positive incremental area under the curve; -1.1 mmol/L·7 h; 95% confidence interval, -2.0 to -0.1). In the morning (08:00-11:00), postprandial glucose decreased during the 4 × 5 minutes and 6 × 5 minutes conditions (positive incremental area under the curve; -0.8 mmol/L·3 h; 95% confidence interval, -1.3 to -0.3 and -0.8 mmol/L·3 h; 95% confidence interval, -1.5 to -0.2, respectively) compared with prolonged sitting. Interrupting 8 hours of prolonged sitting at least every 90 minutes with light-intensity standing-based exercises attenuates postprandial glucose in stroke survivors. During the morning, postprandial glucose is attenuated when sitting is interrupted every 60 and 90 minutes.