Prediction of treatment response from the microenvironment of tumor immunity in cervical cancer patients treated with chemoradiotherapy

To supplement clinical decision-making in the management of cervical cancer, various prognostic factors, including tumor immune microenvironments, were examined in patients with cervical cancer treated with definitive chemoradiotherapy. We retrospectively analyzed the expression of CD8, FoxP3, HLA-1...

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Bibliographic Details
Published in:Medical molecular morphology 2021-09, Vol.54 (3), p.245-252
Main Authors: Someya, Masanori, Tsuchiya, Takaaki, Fukushima, Yuki, Hasegawa, Tomokazu, Hori, Masakazu, Kitagawa, Mio, Gocho, Toshio, Mafune, Shoh, Ikeuchi, Yutaro, Hirohashi, Yoshihiko, Torigoe, Toshihiko, Iwasaki, Masahiro, Matsuura, Motoki, Saito, Tsuyoshi, Matsumoto, Yoshihisa, Sakata, Koh-ichi
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Anatomy
B7-H1 Antigen - genetics
Cancer therapies
CD8 antigen
CD8 Antigens - genetics
Cervical cancer
Cervix
Chemoradiotherapy
Chemotherapy
Decision making
DNA-Binding Proteins - genetics
Female
Forkhead Transcription Factors - genetics
Foxp3 protein
Gene Expression Regulation, Neoplastic
Histocompatibility antigen HLA
Humans
Immunity
Inflammation
Japan
Lymphocytes T
Medical prognosis
Medicine
Medicine & Public Health
Microenvironments
Middle Aged
Molecular Medicine
Multivariate analysis
Original Paper
Pathology
Patients
PD-L1 protein
Prognosis
Radiation therapy
Retrospective Studies
Tumor Microenvironment - immunology
Tumors
Uterine Cervical Neoplasms - genetics
Uterine Cervical Neoplasms - immunology
Uterine Cervical Neoplasms - metabolism
Uterine Cervical Neoplasms - therapy
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Summary:To supplement clinical decision-making in the management of cervical cancer, various prognostic factors, including tumor immune microenvironments, were examined in patients with cervical cancer treated with definitive chemoradiotherapy. We retrospectively analyzed the expression of CD8, FoxP3, HLA-1, PD-L1, and XRCC4 in 100 cases of cervical cancer. The observed tumor immune microenvironments were also classified into three types: inflamed, excluded, and cold type. Less FoxP3+ T cells and cold-type tumor were found to be poor prognostic factors in addition to non-SCC, large pre-treatment tumor volume, and three or less cycles of concurrent chemotherapy based on multivariate analysis. Cold-type tumors had significantly worse prognoses than the other two types, whereas inflamed- and excluded-type tumors showed similar 5-year disease-specific survival ( P  
ISSN:1860-1480
1860-1499
DOI:10.1007/s00795-021-00290-w