Bone turnover markers are associated with the PTH levels in different subtypes of pseudohypoparathyroidism type 1 patients

• Published in: Clinical endocrinology (Oxford) 2021-08, Vol.95 (2), p.277-285
• Main Authors: Duan, Xiaoye, Yang, Yi, Wang, Ou, Nie, Min, Chu, Xueying, Quan, Tingting, Guan, Wenmin, Jiang, Yan, Li, Mei, Xia, Weibo, Xing, Xiaoping
• Format: Article
• Language: English
• Subjects: Adult; Alkaline phosphatase; Biomarkers; Bone Remodeling; bone responsiveness; Bone turnover; bone turnover markers; Calcium (urinary); Collagen Type I; Humans; Hypoparathyroidism; molecular subtype; Parathyroid; Parathyroid Hormone; Pseudohypoparathyroidism; Retrospective Studies
• ISSN: 0300-0664; 1365-2265
• DOI: 10.1111/cen.14496

Objective Bone responsiveness to parathyroid hormone (PTH) in different subtypes of pseudohypoparathyroidism type 1 (PHP1) remains controversial. We aimed to investigate this phenomenon using bone turnover markers (BTMs) in a large cohort of PHP1 patients. Design Retrospective study. Patients Sixty‐three PHP1 patients diagnosed by molecular analysis were used as subjects, and 48 sex‐ and age‐matched patients with nonsurgical hypoparathyroidism (NS‐HP) were used for comparison. Measurements Bone turnover markers, alkaline phosphatase (ALP), C‐terminal telopeptide of type I collagen (β‐CTX) and related parameters in PHP1 were compared among different subtypes and with NS‐HP. Results Among all the PHP1 patients (15 PHP1A, 14 familial 1B and 34 sporadic 1B), 23.8% had elevated baseline BTM levels. No significant difference was found in the β‐CTX levels among different subtypes. The β‐CTX level was positively correlated with the PTH level for all PHP1, PHP1B and PHP1A patients (B = 0.001, 0.001 and 0.004, respectively; all p