Role of lymphadenectomy for apparent early stage uterine sarcoma; a comprehensive analysis of the National Cancer Database

Investigate the role of lymphadenectomy for patients with apparent stage I uterine sarcoma. The National Cancer Database was accessed and patients without a history of another tumor diagnosed between 2004 and 2015 with an apparent early stage leiomyosarcoma, adenosarcoma, low-grade endometrial strom...

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Bibliographic Details
Published in:Surgical oncology 2021-09, Vol.38, p.101589-101589, Article 101589
Main Authors: Nasioudis, Dimitrios, Mastroyannis, Spyridon A., Latif, Nawar A., Ko, Emily M., Haggerty, Ashley F., Kim, Sarah H., Morgan, Mark A., Giuntoli, Robert L.
Format: Article
Language:English
Subjects:
Cancer
Cancer therapies
Chemotherapy
Endometrium
Female
Follow-Up Studies
Histology
Humans
Hysterectomy
Hysterectomy - mortality
Leiomyosarcoma - pathology
Leiomyosarcoma - surgery
Lymph Node Excision - mortality
Lymph nodes
Lymphatic system
Metastases
Metastasis
Middle Aged
Pathology
Patients
Prognosis
Radiation therapy
Rank tests
Sarcoma
Sarcoma, Endometrial Stromal - pathology
Sarcoma, Endometrial Stromal - surgery
Survival
Survival Rate
Uterine cancer
Uterine Neoplasms - pathology
Uterine Neoplasms - surgery
Uterus
Variables
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Summary:Investigate the role of lymphadenectomy for patients with apparent stage I uterine sarcoma. The National Cancer Database was accessed and patients without a history of another tumor diagnosed between 2004 and 2015 with an apparent early stage leiomyosarcoma, adenosarcoma, low-grade endometrial stromal and high-grade endometrial stromal/undifferentiated sarcoma who underwent hysterectomy with or without lymphadenectomy were identified. Overall survival was assessed after stratification by histology with the log-rank test while Cox models were constructed to control for confounders. A total of 6412 patients with apparent early stage uterine sarcoma who underwent hysterectomy were identified; 2820 (44%) underwent lymphadenectomy. Rate of lymph node metastasis was 3.4% (42/1250) for patients with leiomyosarcoma, 2.3% (19/826) for those with adenosarcoma, 4.5% (21/463) for patients with low-grade endometrial stromal sarcoma and 7.9% (22/280) for those with high-grade endometrial stromal/undifferentiated sarcoma, p 
ISSN:0960-7404
1879-3320
DOI:10.1016/j.suronc.2021.101589