The role of active metabolites isolated from Jasminum multiflorum flowers against hepatitis C virus infection and related hepatocellular carcinoma

Jasminum Burm. f. ( is an ornamental plant with traditional medicinal importance. This study aims to evaluate the activity of isolated compounds against hepatocellular carcinoma cells infected with hepatitis C virus (HCV) . The anti-viral and anti-oncogenic-related activity were validated by anchora...

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Bibliographic Details
Published in:Natural product research 2022-05, Vol.36 (10), p.2625-2629
Main Authors: El-Hawary, Seham S, El-Hefnawy, Hala M, Elemeery, Moustafa N, Osman, Samir M, El-Raey, Mohamed A, Mokhtar, Fatma Alzahraa, Pan, Cheol H, Ibrahim, Haitham Ali
Format: Article
Language:English
Subjects:
Anti-oncogenes
Antiviral agents
EphA2 protein
Flowers
Hepatitis
Hepatitis C
Hepatocellular carcinoma
Jasminum multiflorum
Medicinal plants
Metabolites
Molecular docking
Ornamental plants
Viruses
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Summary:Jasminum Burm. f. ( is an ornamental plant with traditional medicinal importance. This study aims to evaluate the activity of isolated compounds against hepatocellular carcinoma cells infected with hepatitis C virus (HCV) . The anti-viral and anti-oncogenic-related activity were validated by anchorage-independent assay plus transwell migration/invasion and spreading assay. In addition to chromatographic isolation of the active metabolites. The flower extract demonstrated a significant antiviral potential through reducing active viral replication by more than 90%. Study results credit this to specific reduction of viral NS5A and cellular EphA2 protein levels. Molecular docking analysis proved the role of the isolated compounds especially multifloroside, jasfloroside A and jasfloroside B as possible anti HCV molecules.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2021.1913588