Asymmetric Reduction of Aromatic α-Dehydroamino Acid Esters with Water as Hydrogen Source

The asymmetric reduction of aromatic α-dehydroamino acid esters with water as the hydrogen source was developed by a Rh/Cu co-catalytic system. The reaction tolerates various functional groups, providing a valuable synthetic tool to access chiral α-amino acid esters readily. Moreover, the present me...

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Bibliographic Details
Published in:Journal of organic chemistry 2021-05, Vol.86 (10), p.7141-7147
Main Authors: Dai, Yuze, Chen, Jingchao, Wang, Zheting, Wang, Ting, Wang, Lin, Yang, Yong, Qiao, Xingfang, Fan, Baomin
Format: Article
Language:English
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Summary:The asymmetric reduction of aromatic α-dehydroamino acid esters with water as the hydrogen source was developed by a Rh/Cu co-catalytic system. The reaction tolerates various functional groups, providing a valuable synthetic tool to access chiral α-amino acid esters readily. Moreover, the present methodology also was applied in the cost-effective and easy to handle preparation of chiral deuterated α-amino esters by using D O.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.1c00426