Radiomics analysis of contrast-enhanced CT for classification of hepatic focal lesions in colorectal cancer patients: its limitations compared to radiologists

• Published in: European radiology 2021-11, Vol.31 (11), p.8786-8796
• Main Authors: Bae, Heejin, Lee, Hansang, Kim, Sungwon, Han, Kyunghwa, Rhee, Hyungjin, Kim, Dong-kyu, Kwon, Hyuk, Hong, Helen, Lim, Joon Seok
• Format: Article
• Language: English
• Subjects: Cancer; Colorectal cancer; Colorectal carcinoma; Computed tomography; Cysts; Diagnostic Radiology; Diagnostic systems; Hemangioma; Image classification; Image contrast; Image enhancement; Imaging; Imaging Informatics and Artificial Intelligence; Internal Medicine; Interventional Radiology; Lesions; Liver; Liver cancer; Magnetic resonance imaging; Medical imaging; Medicine; Medicine & Public Health; Metastases; Metastasis; Neuroradiology; Performance evaluation; Radiology; Radiomics; Subgroups; Ultrasound
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-021-07877-y

Objective To evaluate diagnostic performance of a radiomics model for classifying hepatic cyst, hemangioma, and metastasis in patients with colorectal cancer (CRC) from portal-phase abdominopelvic CT images. Methods This retrospective study included 502 CRC patients who underwent contrast-enhanced CT and contrast-enhanced liver MRI between January 2005 and December 2010. Portal-phase CT images of training ( n  = 386) and validation ( n  = 116) cohorts were used to develop a radiomics model for differentiating three classes of liver lesions. Among multiple handcrafted features, the feature selection was performed using ReliefF method, and random forest classifiers were used to train the selected features. Diagnostic performance of the developed model was compared with that of four radiologists. A subgroup analysis was conducted based on lesion size. Results The radiomics model demonstrated significantly lower overall and hemangioma- and metastasis-specific polytomous discrimination index (PDI) (overall, 0.8037; hemangioma-specific, 0.6653; metastasis-specific, 0.8027) than the radiologists (overall, 0.9622–0.9680; hemangioma-specific, 0.9452–0.9630; metastasis-specific, 0.9511–0.9869). For subgroup analysis, the PDI of the radiomics model was different according to the lesion size (< 10 mm, 0.6486; ≥ 10 mm, 0.8264) while that of the radiologists was relatively maintained. For classifying metastasis from benign lesions, the radiomics model showed excellent diagnostic performance, with an accuracy of 84.36% and an AUC of 0.9426. Conclusion Albeit inferior to the radiologists, the radiomics model achieved substantial diagnostic performance when differentiating hepatic lesions from portal-phase CT images of CRC patients. This model was limited particularly to classifying hemangiomas and subcentimeter lesions. Key Points • Albeit inferior to the radiologists, the radiomics model could differentiate cyst, hemangioma, and metastasis with substantial diagnostic performance using portal-phase CT images of colorectal cancer patients. • The radiomics model demonstrated limitations especially in classifying hemangiomas and subcentimeter liver lesions.