Systematic review and network analysis of microRNAs involved in cardioprotection against myocardial ischemia/reperfusion injury and infarction: Involvement of redox signalling

• Published in: Free radical biology & medicine 2021-08, Vol.172, p.237-251
• Main Authors: Makkos, András, Ágg, Bence, Petrovich, Balázs, Varga, Zoltán V., Görbe, Anikó, Ferdinandy, Péter
• Format: Article
• Language: English
• Subjects: Cardioprotection; Ischemia-reperfusion injury; microRNA; miRNA; Oxidative-stress; protectomiR; Revers miRNA target prediction; Unbiased bioinformatics
• ISSN: 0891-5849; 1873-4596
• DOI: 10.1016/j.freeradbiomed.2021.04.034

Although myocardial ischemia-reperfusion injury (I/R) and its pathological consequences are the leading cause of morbidity and mortality worldwide, cardioprotective therapeutics are still not on the market. Oxidative stress, a major contributing factor to myocardial I/R, changes transcription of coding and non-coding RNAs, alters post-transcriptional modulations, and regulate protein function. MicroRNA (miRNA) expression can be altered by oxidative stress and microRNAs may also regulate cytoprotective mechanisms and exert cardioprotection againts I/R. Transcriptomic analysis of I/R and oxidative stress-induced alterations followed by microRNA-mRNA target interaction network analysis may reveal microRNAs and their mRNA targets that may play a role in cardioprotection and serve as microRNA therapeutics or novel molecular targets for further drug development. Here we provide a summary of a systematic literature review and in silico molecular network analysis to reveal important cardioprotective microRNAs and their molecular targets that may provide cardioprotection via regulation of redox signalling. [Display omitted] •Oxidative stress, a major contributing factor to myocardial I/R injury, changes transcription of coding and non-coding RNAs.•microRNAs may regulate cytoprotective mechanisms and exert cardioprotection against I/R injury.•Analysis of I/R- and oxidative stress-induced alterations may reveal novel molecular targets for further drug development.•microRNA-mRNA target interaction network analysis may reveal miRNA therapeutics.•Systematic literature review and network analysis resulted cardioprotective microRNAs in association redox signaling.