Stopping the Clock on Seizures

A recent paper by Zhang et al. shows that REV-ERBα, a negative regulator of the circadian molecular clock, is pro-convulsant through its action on GABA signaling. The findings support the role of the circadian molecular clock in epilepsy and suggest REV-ERBα as a potential therapeutic target for the...

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Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 2021-06, Vol.44 (6), p.422-423
Main Authors: Fu, Xiaoqin, Liu, Judy S., Li, Peijun
Format: Article
Language:English
Subjects:
Circadian Clocks
circadian molecular clock
Circadian Rhythm
epilepsy
Humans
Nuclear Receptor Subfamily 1, Group D, Member 1 - metabolism
Seizures
Signal Transduction
tonic GABA
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Summary:A recent paper by Zhang et al. shows that REV-ERBα, a negative regulator of the circadian molecular clock, is pro-convulsant through its action on GABA signaling. The findings support the role of the circadian molecular clock in epilepsy and suggest REV-ERBα as a potential therapeutic target for the management of seizures.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2021.04.002