Organophosphorus pesticide exposure biomarkers in a Mexican population

The organophosphate (OP) pesticides are neurotoxic compounds widely used around the world. Evaluation of OP exposure in human studies is important for enabling adequate data analyses and drawing accurate conclusions. The aim of this study was to analyze OP exposure biomarkers and their relationships...

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Bibliographic Details
Published in:Environmental science and pollution research international 2021-09, Vol.28 (36), p.50825-50834
Main Authors: Herrera-Moreno, José Francisco, Medina-Díaz, Irma Martha, Bernal-Hernández, Yael Yvette, Barrón-Vivanco, Briscia Socorro, González-Arias, Cyndia Azucena, Moreno-Godínez, Ma. Elena, Verdín-Betancourt, Francisco Alberto, Sierra-Santoyo, Adolfo, Rojas-García, Aurora Elizabeth
Format: Article
Language:English
Subjects:
Acetylcholinesterase
Albumin
Albumins
Aquatic Pollution
Arylesterase
Atmospheric Protection/Air Quality Control/Air Pollution
Biomarkers
Butyrylcholinesterase
Cholinesterase
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental science
Exposure
Gas chromatography
Humans
Mass spectrometry
Mass spectroscopy
Metabolites
Mexico
Neurotoxicity
Occupational Exposure
Organophosphates
Organophosphorus Compounds
Organophosphorus pesticides
Paraoxonase
Paraoxonase 1
Pesticides
Research Article
Spectrophotometry
Waste Water Technology
Water Management
Water Pollution Control
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Summary:The organophosphate (OP) pesticides are neurotoxic compounds widely used around the world. Evaluation of OP exposure in human studies is important for enabling adequate data analyses and drawing accurate conclusions. The aim of this study was to analyze OP exposure biomarkers and their relationships in a Mexican population with different exposure levels. Dialkylphosphates (DAP) were determined through gas chromatography-mass spectrometry (GC-MSD); acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), arylesterase (AREase), basal paraoxonase 1 (PONase), and β-glucuronidase activities were detected using spectrophotometric methods. The albumin content was determined in a certified clinical laboratory. The DMTP metabolite was found in the highest concentration, and a negative and significant correlation between DAP and cholinesterase activity was observed. Our results suggested that BuChE is a considerably more sensitive biomarker than AChE. In addition, β-glucuronidase was positively correlated with albumin, BuChE, and PONase. In conclusion, our data strongly support the use of two or more biomarkers of exposure in human monitoring and the application of a strong and validated questionnaire.
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-021-14270-1