Salvage interstitial laser thermal therapy under MRI guidance (MRgFLA) for high-intensity focal ultrasound (HIFU) recurrences: feasibility study

While focal therapy (FT) is increasingly endorsed for treating localized prostate cancer in the appropriately selected patient, management of recurrences following FT is not well-established in the literature. This case series describes three patients who received high-intensity focal ultrasound (HI...

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Bibliographic Details
Published in:Clinical imaging 2021-08, Vol.76, p.217-221
Main Authors: Magee, Diana, Perlis, Nathan, Corr, Kateri, Chan, Rosanna, Gertner, Mark, Zisman, Alexander, Jokhu, Sarah, Ghai, Sangeet
Format: Article
Language:English
Subjects:
Ablation
Biopsy
Cancer therapies
Clinical trials
Cysts
Erectile dysfunction
Failure
Feasibility studies
Focal therapy
HIFU
Laser
Lasers
Magnetic resonance imaging
Patients
Prostate cancer
Radiation
Salvage treatment
Therapy
Ultrasonic imaging
Ultrasound
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Description
Summary:While focal therapy (FT) is increasingly endorsed for treating localized prostate cancer in the appropriately selected patient, management of recurrences following FT is not well-established in the literature. This case series describes three patients who received high-intensity focal ultrasound (HIFU) for primary treatment followed by focal laser interstitial thermal therapy (FLTT) for salvage therapy treated in the context of an ongoing clinical trial. Evaluation of these reported patients demonstrates that FLTT is feasible in the salvage setting with promising short-term oncologic outcomes and with the potential to preserve functional outcomes. Repeat focal therapy for previous failures is feasible however, it requires sophisticated imaging modalities for the accurate identification of recurrence and treatment of the tumor. •This is the first case series describing the treatment of HIFU failures using focal laser ablation therapy•Focal therapy has resulted in excellent short term oncologic control and preservation of functional status•The management of HIFU failures with focal therapy requires advanced imaging
ISSN:0899-7071
1873-4499
DOI:10.1016/j.clinimag.2021.04.014