Altered Sensory Representations in Parkinsonian Cortical and Basal Ganglia Networks

• Published in: Neuroscience 2021-07, Vol.466, p.10-25
• Main Authors: Peña-Rangel, Teresa M., Lugo-Picos, Paola Isabel, Báez-Cordero, Ana Silvia, Hidalgo-Balbuena, Ana Elizabeth, Luma, Annie Yolene, Pimentel-Farfan, Ana Karen, Rueda-Orozco, Pavel E.
• Format: Article
• Language: English
• Subjects: basal ganglia; Parkinson’s disease; sensory processing
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2021.04.031

•Sensory processing was studied in Parkinsonian cortico-basal ganglia networks.•Subjects presented abnormal sensory-evoked neural population dynamics.•Subjects presented impaired sensory-related cortico-basal ganglia interactions.•Striatal lesions partially recovered neural population dynamics and motor function. In parkinsonian conditions, network dynamics in the cortical and basal ganglia circuits present abnormal oscillations and periods of high synchrony, affecting the functionality of multiple striatal regions including the sensorimotor striatum. However, it is still unclear how these altered dynamics impact on sensory processing, a key feature for motor control that is severely impaired in parkinsonian patients. A major confound is that pathological dynamics in sensorimotor networks may elicit unspecific motor responses that may alter sensory representations through sensory feedback, making it difficult to disentangle motor and sensory components. To address this issue, we studied sensory processing using an anesthetized model with robust sensory representations throughout cortical and basal ganglia sensory regions and limited motor confounds in control and hemiparkinsonian rats. A general screening of sensory-evoked activity in large populations of neurons recorded in the primary sensory cortex (S1), dorsolateral striatum (DLS) and substantia nigra pars reticulata (SNr) revealed increased excitability and altered sensory representations in the three regions. Further analysis revealed uncoordinated population dynamics between DLS and S1/SNr. Finally, DLS lesions in hemiparkinsonian animals partially recovered population dynamics and execution in the rotarod.