Fish oil supplementation increases expression of mammary tumor apoptosis mediators and reduces inflammation in an obesity-associated HER-2 breast cancer model

Obesity is associated with inflammation and has been shown to increase breast cancer severity. The objective of this study was to examine the effect of fish oil (FO) supplementation in obesity-associated mammary tumorigenesis in the MMTV-neu(ndl)-YD5 mouse model of human epidermal growth factor rece...

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Published in:The Journal of nutritional biochemistry 2021-09, Vol.95, p.108763-108763, Article 108763
Main Authors: Monk, Jennifer M., Liddle, Danyelle M., Hutchinson, Amber L., Burns, Jessie L., Wellings, Hannah, Cartwright, Nadia M., Muller, William J, Power, Krista A., Robinson, Lindsay E., Ma, David W.L.
Format: Article
Language:English
Subjects:
Breast cancer
Fish oil
Human epidermal growth factor receptor 2
Inflammation
n-3 PUFA
Obesity
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Summary:Obesity is associated with inflammation and has been shown to increase breast cancer severity. The objective of this study was to examine the effect of fish oil (FO) supplementation in obesity-associated mammary tumorigenesis in the MMTV-neu(ndl)-YD5 mouse model of human epidermal growth factor receptor-2 positive BC. Female mice were fed one of three diets for 16 weeks: i) high fat diet [HF, % kacl: 41.2% lard, 18.7% corn oil (CO)], ii) an isocaloric HF plus menhaden FO diet (HF+FO, % kcal: 41.2 lard, 13.4% CO, 5.3% FO), iii) low fat diet (LF, % kcal: 4.7% lard, 6% CO). HF mice had increased body weight, visceral adipose weight and serum hormone concentrations (increased leptin and resistin; decreased adiponectin) versus LF, which was attenuated in the HF+FO group versus HF (P
ISSN:0955-2863
1873-4847
DOI:10.1016/j.jnutbio.2021.108763