Natural products as geroprotectors: An autophagy perspective

Over the past decade, significant attention has been given to repurposing Food and Drug Administration approved drugs to treat age‐related diseases. In contrast, less consideration has been given to natural bioactive compounds. Consequently, there have been limited attempts to translate these compou...

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Bibliographic Details
Published in:Medicinal research reviews 2021-11, Vol.41 (6), p.3118-3155
Main Authors: Raj, Stephen D., Fann, David Y., Wong, Esther, Kennedy, Brian K.
Format: Article
Language:English
Subjects:
ageing
Autophagy
drug discovery
fatty acids and phospholipids
FDA approval
geroscience
lipids
lithium
Natural products
resveratrol
spermidine
trehalose
Urolithin A
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Summary:Over the past decade, significant attention has been given to repurposing Food and Drug Administration approved drugs to treat age‐related diseases. In contrast, less consideration has been given to natural bioactive compounds. Consequently, there have been limited attempts to translate these compounds. Autophagy is a fundamental biological pathway linked to aging, and numerous strategies to enhance autophagy have been shown to extend lifespan. Interestingly, there are a number of natural products that are reported to modulate autophagy, and here we describe a number of them that activate autophagy through diverse molecular and cellular mechanisms. Among these, Urolithin A, Spermidine, Resveratrol, Fatty Acids and Phospholipids, Trehalose and Lithium are featured in detail. Finally, we outline possible strategies to optimise and increase the translatability of natural products, with the overall aim of delaying the ageing process and improving human healthspan.
ISSN:0198-6325
1098-1128
DOI:10.1002/med.21815