Acmella oleracea extract increases collagen content and organization in partially transected tendons

Acmella oleracea contains spilanthol as the main active compound, which possesses analgesic and anti‐inflammatory effects that can favor tendon reorganization. To analyze the effect of A. oleracea on the content and organization of collagen in injured tendons, the calcaneal tendon of male Lewis rats...

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Bibliographic Details
Published in:Microscopy research and technique 2021-11, Vol.84 (11), p.2588-2597
Main Authors: Moro, Selma Delgado de Souza, Fujii, Lucas, Teodoro, Luis Felipe Rodrigues, Frauz, Katleen, Mazoni, Alysson Fernandes, Esquisatto, Marcelo Augusto Maretto, Rodrigues, Rodney Alexandre Ferreira, Pimentel, Edson Rosa, Aro, Andrea Aparecida
Format: Article
Language:English
Subjects:
Acmella oleracea
Analgesics
Biomechanics
Birefringence
Blood vessels
calcaneal tendon
Calcaneus
Collagen
Fibroblasts
Inflammation
Load distribution
Ointments
Plant extracts
Proteoglycans
repair
Tendons
Topical application
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Summary:Acmella oleracea contains spilanthol as the main active compound, which possesses analgesic and anti‐inflammatory effects that can favor tendon reorganization. To analyze the effect of A. oleracea on the content and organization of collagen in injured tendons, the calcaneal tendon of male Lewis rats was partially transected and treated at the site of injury with a topical application of 20% A. oleracea ointment (AO group) or with the ointment base without the plant extract (B group). The animals were euthanized 21 days after partial transection. Higher collagen concentration was observed in the AO group than in the B group, and morphological analysis using polarization microscopy showed higher birefringence in the AO group than in the B group, indicating higher collagen organization. No difference was observed in the number of fibroblasts, blood vessels, proteoglycan distribution, and maximum load between the B and AO groups. In conclusion, topical application of 20% A. oleracea ointment increased the molecular organization and content of collagen, thus indicating a potential application in tendon repair. Studies on the later phases of the tendon healing process are necessary to demonstrate the possible biomechanical changes after the application of A. oleracea ointment. Acmella oleracea ointment is a potential treatment for tendon repair. 20% A. oleracea ointment increases organization of collagen. Collagen content is augmented with plant ointment.
ISSN:1059-910X
1097-0029
DOI:10.1002/jemt.23809