Update on pediatric testicular germ cell tumors

Testicular germ cell tumors are uncommon tumors that are encountered by pediatric surgeons and urologists and require a knowledge of appropriate contemporary evaluation and surgical and medical management. A review of the recommended diagnostic evaluation and current surgical and medical management...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pediatric surgery 2022-04, Vol.57 (4), p.690-699
Main Authors: Aldrink, Jennifer H., Glick, Richard D., Baertschiger, Reto M., Kulaylat, Afif N., Lautz, Timothy B., Christison-Lagay, Emily, Grant, Christa N., Tracy, Elisabeth, Dasgupta, Roshni, Brown, Erin G., Mattei, Peter, Rothstein, David H., Rodeberg, David A., Ehrlich, Peter F.
Format: Article
Language:English
Subjects:
Adolescent
Child
Humans
Lymph Node Excision
Male
Neoplasm Staging
Neoplasms, Germ Cell and Embryonal - diagnosis
Neoplasms, Germ Cell and Embryonal - pathology
Neoplasms, Germ Cell and Embryonal - therapy
Orchiectomy
Pediatric
Prospective Studies
Retroperitoneal lymph node dissection
Testicular germ cell malignancy
Testicular Neoplasms - drug therapy
Testicular Neoplasms - therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Testicular germ cell tumors are uncommon tumors that are encountered by pediatric surgeons and urologists and require a knowledge of appropriate contemporary evaluation and surgical and medical management. A review of the recommended diagnostic evaluation and current surgical and medical management of children and adolescents with testicular germ cell tumors based upon recently completed clinical trials was performed and summarized in this article. In this summary of childhood and adolescent testicular germ cell tumors, we review the initial clinical evaluation, surgical and medical management, risk stratification, results from recent prospective cooperative group studies, and clinical outcomes. A summary of recently completed clinical trials by pediatric oncology cooperative groups is provided, and best surgical practices are discussed. Testicular germ cell tumors in children are rare tumors. International collaborations, data-sharing, and enrollment of patients at all stages and risk classifications into active clinical trials will enhance our knowledge of these rare tumors and most importantly improve outcomes of patients with testicular germ cell tumors. This is a review article of previously published and referenced level 1 and 2 studies, but also includes expert opinion level 5, represented by the American Pediatric Surgical Association Cancer Committee.
ISSN:0022-3468
1531-5037
DOI:10.1016/j.jpedsurg.2021.04.001