Relationship between miR-155 expression and clear cell papillary renal cell carcinoma in the dialyzed kidney

• Published in: IJU case reports 2021, Vol.4 (3), p.127-131
• Main Authors: Shiomi, Ei, Kato, Renpei, Matsuura, Tomohiko, Maekawa, Shigekatsu, Kato, Yoichiro, Kanehira, Mitsugu, Takata, Ryo, Sugimura, Jun, Ishida, Kazuyuki, Abe, Takaya, Sugai, Tamotsu, Obara, Wataru
• Format: Report
• Language: English
• ISSN: 2577-171X
• DOI: 10.1002/iju5.12258

INTRODUCTIONClear cell papillary renal cell carcinoma often develops in the context of the dialyzed kidney (end-stage renal disease). However, the relationship between clear cell papillary renal cell carcinoma and microRNA expression in patients with end-stage renal disease remains unclear.CASE PRESENTATIONA left renal tumor measuring 22 mm was detected and a radical nephrectomy was performed on a 50-year-old man who had received hemodialysis for the past 6 years. A pathological diagnosis of pT1aNxMx, clear cell papillary renal cell carcinoma was made. We studied the expression of miR-155 in this case and compared it to the expression in nondialysis kidney tissue. The expression level of miR-155 was upregulated in tumor tissue compared with expression levels in the renal cortex for the present case. The expression level of miR-155 in the renal cortex was lower in the present case than in nondialysis kidney tissues.CONCLUSIONWe demonstrated upregulation of miR-155 in a case of clear cell papillary renal cell carcinoma arising from end-stage renal disease.