Effects of garlic powder supplementation on metabolic syndrome components, insulin resistance, fatty liver index, and appetite in subjects with metabolic syndrome: A randomized clinical trial

The prevalence of metabolic syndrome (MetS) is increasing. It is closely linked to nonalcoholic fatty liver disease. Garlic consumption as a strategy for the management of MetS has been suggested. We investigated the effect of garlic supplementation on MetS components, insulin resistance, fatty live...

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Bibliographic Details
Published in:Phytotherapy research 2021-08, Vol.35 (8), p.4433-4441
Main Authors: Sangouni, Abbas Ali, Alizadeh, Mohammad, Jamalzehi, Atena, Parastouei, Karim
Format: Article
Language:English
Subjects:
Appetite
Blood pressure
Cholesterol
Fatty liver
fatty liver index
Garlic
Hunger
Indexing
Insulin
Insulin resistance
Liver
Liver diseases
Metabolic disorders
Metabolic syndrome
Placebos
Supplements
Triglycerides
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Summary:The prevalence of metabolic syndrome (MetS) is increasing. It is closely linked to nonalcoholic fatty liver disease. Garlic consumption as a strategy for the management of MetS has been suggested. We investigated the effect of garlic supplementation on MetS components, insulin resistance, fatty liver index (FLI), and appetite in subjects with MetS. Ninety subjects were assigned to receive 1,600 mg/d garlic powder or placebo for 3 months. The primary outcomes included MetS components. The secondary outcomes included insulin resistance, FLI, and appetite. Garlic supplementation compared with the placebo led to a significant increase in high density lipoprotein‐cholesterol (4.5 vs. −1.8, p 
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.7146