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Malignancies requiring temporal bone resection: An Australian single‐institution experience
Background Malignancies in and around the temporal bone are aggressive and difficult to manage. In Queensland (Australia), where skin cancer rates are exceedingly high, tumours extending to the temporal bone from surrounding structures occur more commonly than primary cancers. Yet, a paucity of evid...
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| Published in: | ANZ journal of surgery 2021-07, Vol.91 (7-8), p.1462-1471 |
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| container_title | ANZ journal of surgery |
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| creator | Schachtel, Michael J. C. Gandhi, Mitesh Bowman, James J. Erian, Christopher Porceddu, Sandro V. Panizza, Benedict J. |
| description | Background
Malignancies in and around the temporal bone are aggressive and difficult to manage. In Queensland (Australia), where skin cancer rates are exceedingly high, tumours extending to the temporal bone from surrounding structures occur more commonly than primary cancers. Yet, a paucity of evidence exists as to their management and outcomes. This study aimed to review an Australian centre's experience of managing temporal and peritemporal bone malignancies, reporting on patient and tumour characteristics, treatment, and survival outcomes.
Methods
Retrospective analysis of patients with primary temporal bone cancer and cancers extending to the temporal bone managed by the Queensland Skull Base Unit (Princess Alexandra Hospital) between 2000 and 2019.
Results
A total of 222 patients were identified, of which 203 (91.4%) had cutaneous primaries, with 167 (75.2%) being squamous cell carcinoma (SCC). 73.9% presented with locoregionally recurrent or residual disease. Secondary tumours (92.8%) were 12 times more frequent than primary malignancies (7.2%), with the preauricular subsite the most common (45.5%). In the 201 patients (90.5%) who underwent curative intent surgery, 5‐year overall survival, disease‐free survival (DFS), and disease‐specific survival was 46.6%, 52.2%, and 65.9%, respectively. The preauricular subsite (p = 0.004), melanoma (vs. SCC, p = 0.027), involved margins (p |
| doi_str_mv | 10.1111/ans.16931 |
| format | article |
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Malignancies in and around the temporal bone are aggressive and difficult to manage. In Queensland (Australia), where skin cancer rates are exceedingly high, tumours extending to the temporal bone from surrounding structures occur more commonly than primary cancers. Yet, a paucity of evidence exists as to their management and outcomes. This study aimed to review an Australian centre's experience of managing temporal and peritemporal bone malignancies, reporting on patient and tumour characteristics, treatment, and survival outcomes.
Methods
Retrospective analysis of patients with primary temporal bone cancer and cancers extending to the temporal bone managed by the Queensland Skull Base Unit (Princess Alexandra Hospital) between 2000 and 2019.
Results
A total of 222 patients were identified, of which 203 (91.4%) had cutaneous primaries, with 167 (75.2%) being squamous cell carcinoma (SCC). 73.9% presented with locoregionally recurrent or residual disease. Secondary tumours (92.8%) were 12 times more frequent than primary malignancies (7.2%), with the preauricular subsite the most common (45.5%). In the 201 patients (90.5%) who underwent curative intent surgery, 5‐year overall survival, disease‐free survival (DFS), and disease‐specific survival was 46.6%, 52.2%, and 65.9%, respectively. The preauricular subsite (p = 0.004), melanoma (vs. SCC, p = 0.027), involved margins (p < 0.001), and pathologically involved nodes (p < 0.001) were associated with significantly worse DFS.
Conclusion
This is one of the largest studies of temporal bone malignancy in the literature, comprised primarily of secondary cutaneous malignancies. Although clear differences in epidemiological characteristics exist around the world, survival remains poor. Treatment should focus on achieving a clear margin of resection to optimize outcomes.
This is one of the largest studies of malignancies requiring temporal bone resection in the literature, comprised of both primary temporal bone tumours as well as peritemporal tumours extending to the temporal bone. Survival outcomes remain poor despite the differences in epidemiological characteristics to other locations around the world. Treatment should focus on achieving a clear margin of resection to optimize patient outcomes.</description><identifier>ISSN: 1445-1433</identifier><identifier>EISSN: 1445-2197</identifier><identifier>DOI: 10.1111/ans.16931</identifier><identifier>PMID: 33982375</identifier><language>eng</language><publisher>Melbourne: John Wiley & Sons Australia, Ltd</publisher><subject>Bone cancer ; Cancer ; ear neoplasms ; Epidemiology ; Head & neck cancer ; Malignancy ; Melanoma ; Oral cancer ; parotid neoplasms ; Patients ; Skin cancer ; skin neoplasms ; skull base neoplasms ; Squamous cell carcinoma ; Survival ; Temporal bone ; Tumors</subject><ispartof>ANZ journal of surgery, 2021-07, Vol.91 (7-8), p.1462-1471</ispartof><rights>2021 Royal Australasian College of Surgeons.</rights><rights>2021 Royal Australasian College of Surgeons</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3531-19e6aef3391cc96ffe16f71fc387d03dc919d49a3dc7f06c429b16d18eb6b2b23</citedby><cites>FETCH-LOGICAL-c3531-19e6aef3391cc96ffe16f71fc387d03dc919d49a3dc7f06c429b16d18eb6b2b23</cites><orcidid>0000-0002-1111-3946</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33982375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schachtel, Michael J. C.</creatorcontrib><creatorcontrib>Gandhi, Mitesh</creatorcontrib><creatorcontrib>Bowman, James J.</creatorcontrib><creatorcontrib>Erian, Christopher</creatorcontrib><creatorcontrib>Porceddu, Sandro V.</creatorcontrib><creatorcontrib>Panizza, Benedict J.</creatorcontrib><title>Malignancies requiring temporal bone resection: An Australian single‐institution experience</title><title>ANZ journal of surgery</title><addtitle>ANZ J Surg</addtitle><description>Background
Malignancies in and around the temporal bone are aggressive and difficult to manage. In Queensland (Australia), where skin cancer rates are exceedingly high, tumours extending to the temporal bone from surrounding structures occur more commonly than primary cancers. Yet, a paucity of evidence exists as to their management and outcomes. This study aimed to review an Australian centre's experience of managing temporal and peritemporal bone malignancies, reporting on patient and tumour characteristics, treatment, and survival outcomes.
Methods
Retrospective analysis of patients with primary temporal bone cancer and cancers extending to the temporal bone managed by the Queensland Skull Base Unit (Princess Alexandra Hospital) between 2000 and 2019.
Results
A total of 222 patients were identified, of which 203 (91.4%) had cutaneous primaries, with 167 (75.2%) being squamous cell carcinoma (SCC). 73.9% presented with locoregionally recurrent or residual disease. Secondary tumours (92.8%) were 12 times more frequent than primary malignancies (7.2%), with the preauricular subsite the most common (45.5%). In the 201 patients (90.5%) who underwent curative intent surgery, 5‐year overall survival, disease‐free survival (DFS), and disease‐specific survival was 46.6%, 52.2%, and 65.9%, respectively. The preauricular subsite (p = 0.004), melanoma (vs. SCC, p = 0.027), involved margins (p < 0.001), and pathologically involved nodes (p < 0.001) were associated with significantly worse DFS.
Conclusion
This is one of the largest studies of temporal bone malignancy in the literature, comprised primarily of secondary cutaneous malignancies. Although clear differences in epidemiological characteristics exist around the world, survival remains poor. Treatment should focus on achieving a clear margin of resection to optimize outcomes.
This is one of the largest studies of malignancies requiring temporal bone resection in the literature, comprised of both primary temporal bone tumours as well as peritemporal tumours extending to the temporal bone. Survival outcomes remain poor despite the differences in epidemiological characteristics to other locations around the world. Treatment should focus on achieving a clear margin of resection to optimize patient outcomes.</description><subject>Bone cancer</subject><subject>Cancer</subject><subject>ear neoplasms</subject><subject>Epidemiology</subject><subject>Head & neck cancer</subject><subject>Malignancy</subject><subject>Melanoma</subject><subject>Oral cancer</subject><subject>parotid neoplasms</subject><subject>Patients</subject><subject>Skin cancer</subject><subject>skin neoplasms</subject><subject>skull base neoplasms</subject><subject>Squamous cell carcinoma</subject><subject>Survival</subject><subject>Temporal bone</subject><subject>Tumors</subject><issn>1445-1433</issn><issn>1445-2197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp10L1OwzAUBWALgWgpDLwAisQCQ1vfOHFqtqjiTyowACOKHOemcpU6rZ0IuvEIPCNPgksLAxJefGV_Oro6hBwDHYA_Q2ncALhgsEO6EEVxPwSR7G5niBjrkAPnZpQC5yLeJx3GxChkSdwlL3ey0lMjjdLoAovLVlttpkGD80VtZRXktUH_7lA1ujYXQWqCtHWN_9LSBM7bCj_fP7RxjW7atQnwbYFWo1F4SPZKWTk82t498nx1-TS-6U8erm_H6aSvWMygDwK5xNJvBUoJXpYIvEygVGyUFJQVSoAoIiH9lJSUqygUOfACRpjzPMxD1iNnm9yFrZctuiaba6ewqqTBunVZGIec0Tjm1NPTP3RWt9b47bzikCSxoOvA841StnbOYpktrJ5Lu8qAZuvOM9959t25tyfbxDafY_Erf0r2YLgBr7rC1f9JWXr_uIn8AiK6jS4</recordid><startdate>202107</startdate><enddate>202107</enddate><creator>Schachtel, Michael J. C.</creator><creator>Gandhi, Mitesh</creator><creator>Bowman, James J.</creator><creator>Erian, Christopher</creator><creator>Porceddu, Sandro V.</creator><creator>Panizza, Benedict J.</creator><general>John Wiley & Sons Australia, Ltd</general><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1111-3946</orcidid></search><sort><creationdate>202107</creationdate><title>Malignancies requiring temporal bone resection: An Australian single‐institution experience</title><author>Schachtel, Michael J. C. ; Gandhi, Mitesh ; Bowman, James J. ; Erian, Christopher ; Porceddu, Sandro V. ; Panizza, Benedict J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3531-19e6aef3391cc96ffe16f71fc387d03dc919d49a3dc7f06c429b16d18eb6b2b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bone cancer</topic><topic>Cancer</topic><topic>ear neoplasms</topic><topic>Epidemiology</topic><topic>Head & neck cancer</topic><topic>Malignancy</topic><topic>Melanoma</topic><topic>Oral cancer</topic><topic>parotid neoplasms</topic><topic>Patients</topic><topic>Skin cancer</topic><topic>skin neoplasms</topic><topic>skull base neoplasms</topic><topic>Squamous cell carcinoma</topic><topic>Survival</topic><topic>Temporal bone</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schachtel, Michael J. C.</creatorcontrib><creatorcontrib>Gandhi, Mitesh</creatorcontrib><creatorcontrib>Bowman, James J.</creatorcontrib><creatorcontrib>Erian, Christopher</creatorcontrib><creatorcontrib>Porceddu, Sandro V.</creatorcontrib><creatorcontrib>Panizza, Benedict J.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>ANZ journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schachtel, Michael J. C.</au><au>Gandhi, Mitesh</au><au>Bowman, James J.</au><au>Erian, Christopher</au><au>Porceddu, Sandro V.</au><au>Panizza, Benedict J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Malignancies requiring temporal bone resection: An Australian single‐institution experience</atitle><jtitle>ANZ journal of surgery</jtitle><addtitle>ANZ J Surg</addtitle><date>2021-07</date><risdate>2021</risdate><volume>91</volume><issue>7-8</issue><spage>1462</spage><epage>1471</epage><pages>1462-1471</pages><issn>1445-1433</issn><eissn>1445-2197</eissn><abstract>Background
Malignancies in and around the temporal bone are aggressive and difficult to manage. In Queensland (Australia), where skin cancer rates are exceedingly high, tumours extending to the temporal bone from surrounding structures occur more commonly than primary cancers. Yet, a paucity of evidence exists as to their management and outcomes. This study aimed to review an Australian centre's experience of managing temporal and peritemporal bone malignancies, reporting on patient and tumour characteristics, treatment, and survival outcomes.
Methods
Retrospective analysis of patients with primary temporal bone cancer and cancers extending to the temporal bone managed by the Queensland Skull Base Unit (Princess Alexandra Hospital) between 2000 and 2019.
Results
A total of 222 patients were identified, of which 203 (91.4%) had cutaneous primaries, with 167 (75.2%) being squamous cell carcinoma (SCC). 73.9% presented with locoregionally recurrent or residual disease. Secondary tumours (92.8%) were 12 times more frequent than primary malignancies (7.2%), with the preauricular subsite the most common (45.5%). In the 201 patients (90.5%) who underwent curative intent surgery, 5‐year overall survival, disease‐free survival (DFS), and disease‐specific survival was 46.6%, 52.2%, and 65.9%, respectively. The preauricular subsite (p = 0.004), melanoma (vs. SCC, p = 0.027), involved margins (p < 0.001), and pathologically involved nodes (p < 0.001) were associated with significantly worse DFS.
Conclusion
This is one of the largest studies of temporal bone malignancy in the literature, comprised primarily of secondary cutaneous malignancies. Although clear differences in epidemiological characteristics exist around the world, survival remains poor. Treatment should focus on achieving a clear margin of resection to optimize outcomes.
This is one of the largest studies of malignancies requiring temporal bone resection in the literature, comprised of both primary temporal bone tumours as well as peritemporal tumours extending to the temporal bone. Survival outcomes remain poor despite the differences in epidemiological characteristics to other locations around the world. Treatment should focus on achieving a clear margin of resection to optimize patient outcomes.</abstract><cop>Melbourne</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>33982375</pmid><doi>10.1111/ans.16931</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-1111-3946</orcidid></addata></record> |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Bone cancer Cancer ear neoplasms Epidemiology Head & neck cancer Malignancy Melanoma Oral cancer parotid neoplasms Patients Skin cancer skin neoplasms skull base neoplasms Squamous cell carcinoma Survival Temporal bone Tumors |
| title | Malignancies requiring temporal bone resection: An Australian single‐institution experience |
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