In vivo monitoring of volatile metabolic trajectories enables rapid diagnosis of influenza A infection

We report that influenza A virus infection induces changes in odor traits that could be captured by real-time high-resolution mass spectrometry in a living mouse model. The most striking changes in the volatile metabolites may be associated mostly to glyoxylate/dicarboxylate metabolism.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2021-05, Vol.57 (39), p.4791-4794
Main Authors: Yin, Zhihong, Huang, Wenbo, Singh, Kapil Dev, Chen, Zhaoming, Chen, Xing, Zhou, Zhen, Yang, Zifeng, Sinues, Pablo, Li, Xue
Format: Article
Language:English
Subjects:
Infections
Influenza
Mass spectrometry
Metabolism
Metabolites
Real time
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Description
Summary:We report that influenza A virus infection induces changes in odor traits that could be captured by real-time high-resolution mass spectrometry in a living mouse model. The most striking changes in the volatile metabolites may be associated mostly to glyoxylate/dicarboxylate metabolism.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc01061a