Distinct Pattern of Paracoccidioides lutzii, P. restrepiensis and P. americana Antigens Recognized by IgE in Human Paracoccidioidomycosis

Paracoccidioidomycosis (PCM) is caused by the fungi Paracoccidioides spp. The main antigens recognized by IgE are known for P. brasiliensis species complex, but not for P. lutzii. Current research investigated the major P. lutzii (LDR2) antigens recognized by IgE, in comparison to P. restrepiensis a...

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Bibliographic Details
Published in:Current microbiology 2021-07, Vol.78 (7), p.2608-2614
Main Authors: Assolini, João P., Lenhard-Vidal, Adriane, Bredt, Carla S. de O., Tano, Zuleica N., Sano, Ayako, Cezar-dos-Santos, Fernando, Ono, Mario A., Itano, Eiko N.
Format: Article
Language:English
Subjects:
Antigens
Biomedical and Life Sciences
Biotechnology
Enzyme-linked immunosorbent assay
Immunoblotting
Immunoglobulin E
Immunoglobulin G
Life Sciences
Microbiology
South American blastomycosis
Species
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Summary:Paracoccidioidomycosis (PCM) is caused by the fungi Paracoccidioides spp. The main antigens recognized by IgE are known for P. brasiliensis species complex, but not for P. lutzii. Current research investigated the major P. lutzii (LDR2) antigens recognized by IgE, in comparison to P. restrepiensis and P. americana (former P. brasiliensis species complex), besides IgG recognition. Cell-free antigens (CFA) from P. lutzii (LDR2), P. restrepiensis (B339) and P. americana (LDR3) were analyzed by ELISA and immunoblotting (IB) by detecting specific IgG and IgE from sera from patients with PCM presumable by P. brasiliensis species complex ( n  = 24). Additionally, somatic antigen (SA) was analyzed by IB. P. lutzii (LDR2) antigens showed significantly lower reactivity than P. restrepiensis (B339) and P. americana (LDR3) in ELISA for both IgE and IgG ( p  
ISSN:0343-8651
1432-0991
DOI:10.1007/s00284-021-02508-7