Association of thyroid disorders with gestational diabetes mellitus: a meta-analysis

Purpose The current meta-analysis aimed to evaluate the association of thyroid dysfunction and autoimmunity with gestational diabetes mellitus (GDM). Methods A comprehensive search from PubMed, Embase, MEDLINE, and Cochrane databases until November 2020 was conducted. Fixed-effect model was used to...

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Bibliographic Details
Published in:Endocrine 2021-09, Vol.73 (3), p.550-560
Main Authors: Luo, Jingyi, Wang, Xiaoxia, Yuan, Li, Guo, Lixin
Format: Article
Language:English
Subjects:
Antibodies
Autoimmunity
Diabetes
Diabetes mellitus
Endocrinology
Gestation
Gestational diabetes
Humanities and Social Sciences
Hyperthyroidism
Hypothyroidism
Internal Medicine
Medicine
Medicine & Public Health
Meta-Analysis
multidisciplinary
Science
Thyroid diseases
Thyroid gland
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Summary:Purpose The current meta-analysis aimed to evaluate the association of thyroid dysfunction and autoimmunity with gestational diabetes mellitus (GDM). Methods A comprehensive search from PubMed, Embase, MEDLINE, and Cochrane databases until November 2020 was conducted. Fixed-effect model was used to combine the results when I 2 was 50%. Results A total of 44 studies were included in the meta-analysis. Low FT4 levels were closely related with GDM in the first and second trimesters of gestation. Hypothyroxinemia (OR: 1.45; 95% CI: 1.25, 1.68; P  
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-021-02712-2