Targeting the Gut Microbiota for Remediating Obesity and Related Metabolic Disorders

The rate of obesity is rapidly increasing and has become a health and economic burden worldwide. As recent studies have revealed that the gut microbiota is closely linked to obesity, researchers have used various approaches to modulate the gut microbiota to treat the condition. Dietary composition a...

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Bibliographic Details
Published in:The Journal of nutrition 2021-07, Vol.151 (7), p.1703-1716
Main Authors: Wang, Botao, Wang, Linlin, Wang, Haojue, Dai, Hongyan, Lu, Xianyi, Lee, Yuan-kun, Gu, Zhennan, Zhao, Jianxin, Zhang, Hao, Chen, Wei, Wang, Gang
Format: Article
Language:English
Subjects:
bacterial lipopolysaccharide
Bile acids
Composition
Dietary intake
diets
Digestive system
Energy intake
Energy metabolism
Fatty acids
fecal microbiota transplantation
Fecal microflora
Fermented food
fermented foods
Food plants
Gastrointestinal Microbiome
Gastrointestinal tract
gut microbiota
Humans
Intestinal microflora
Lipopolysaccharides
Metabolic Diseases
Metabolic disorders
Metabolism
Microbiota
Microorganisms
Nutrition
Obesity
Prebiotics
Probiotics
Studies
Transplantation
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Summary:The rate of obesity is rapidly increasing and has become a health and economic burden worldwide. As recent studies have revealed that the gut microbiota is closely linked to obesity, researchers have used various approaches to modulate the gut microbiota to treat the condition. Dietary composition and energy intake strongly affect the composition and function of the gut microbiota. Intestinal microbial changes alter the composition of bile acids and fatty acids and regulate bacterial lipopolysaccharide production, all of which influence energy metabolism and immunity. Evidence also suggests that remodeling the gut microbiota through intake of probiotics, prebiotics, fermented foods, and dietary plants, as well as by fecal microbiota transplantation, are feasible methods to remediate obesity.
ISSN:0022-3166
1541-6100
DOI:10.1093/jn/nxab103