Inhaled levosimendan: New opportunities with an old drug

To the Editor: The accompanying article by Abdelbaser and colleagues in this edition of The Journal of Clinical Anesthesia compares the efficacy of inhaled levosimendan to intravenous levosimendan in reduction of elevated pulmonary artery pressure (PAP) in children that underwent cardiac surgery for...

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Bibliographic Details
Published in:Journal of clinical anesthesia 2021-10, Vol.73, p.110337-110337, Article 110337
Main Authors: Evans, Michael A., Suresh, Santhanam
Format: Article
Language:English
Subjects:
Adults
Anesthesia
Clinical trials
FDA approval
Heart failure
Heart surgery
Hypotension
Mortality
Patients
Potassium
Pulmonary arteries
Pulmonary hypertension
Smooth muscle
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Summary:To the Editor: The accompanying article by Abdelbaser and colleagues in this edition of The Journal of Clinical Anesthesia compares the efficacy of inhaled levosimendan to intravenous levosimendan in reduction of elevated pulmonary artery pressure (PAP) in children that underwent cardiac surgery for repair of left-to-right shunts. [...]the population being studied and the indication for administration should be closely examined going forward. In Abdelbaser's study, all patients with heart failure were excluded, so that the effects of levosimendan could be isolated to just the effects on pulmonary vasculature, as opposed to the mixed picture of increased inotropy and vascular smooth muscle relaxation.
ISSN:0952-8180
1873-4529
DOI:10.1016/j.jclinane.2021.110337