The significance of sialylation on the pathogenesis of Alzheimer’s disease

•ST6Gal-I promotes Aβ peptide aggregation and then accelerates the process of AD.•Gangliosides are essential for the development of the central nervous system.•Sialylated HMOs could improve the cognitive benefits.•CD33 is highly expressed in the brain of AD patients. Sialylation, one of the most com...

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Bibliographic Details
Published in:Brain research bulletin 2021-08, Vol.173, p.116-123
Main Authors: Yang, Kangkang, Yang, Zhaofei, Chen, Xiaofeng, Li, Wenzhe
Format: Article
Language:English
Subjects:
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer’s disease
Animals
Brain - metabolism
Brain - pathology
Glycosylation
Humans
N-Acetylneuraminic Acid - metabolism
Sialic acid
Sialylation
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Summary:•ST6Gal-I promotes Aβ peptide aggregation and then accelerates the process of AD.•Gangliosides are essential for the development of the central nervous system.•Sialylated HMOs could improve the cognitive benefits.•CD33 is highly expressed in the brain of AD patients. Sialylation, one of the most common and complex modes of glycosylation, corresponds with the development of the infant brain and nervous system. The most prevalent neurodegenerative disease is Alzheimer’s disease (AD), which is mainly characterized by cognitive decline and behavioral disorders. However, the relationship between sialylation and AD occurrence is poorly understood. In this article, we reviewed the role of sialylation on the occurrence and development of AD, then discussed the value of sialylation modification for AD diagnosis and treatment.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2021.05.009