Development of temperature dependent oxygen releasable nanofilm by modulating oxidation state of myoglobin

Controlled release of oxygen from myoglobin was achieved by modulating autoxidation of oxymyoglobin using ascorbic acid as a reductant by temperature variation. Long-term storage, prompt release and re-storage of oxygen were also available with this system. Furthermore, 20 nm thick nanofilms compose...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2021-05, Vol.57 (42), p.5131-5134
Main Authors: Tomioka, Daisuke, Nakatsuji, Hirotaka, Miyagawa, Shigeru, Sawa, Yoshiki, Matsusaki, Michiya
Format: Article
Language:English
Subjects:
Ascorbic acid
Autoxidation
Controlled release
Myoglobins
Oxidation
Oxygen
Reducing agents
Temperature dependence
Tissue engineering
Valence
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Summary:Controlled release of oxygen from myoglobin was achieved by modulating autoxidation of oxymyoglobin using ascorbic acid as a reductant by temperature variation. Long-term storage, prompt release and re-storage of oxygen were also available with this system. Furthermore, 20 nm thick nanofilms composed of oxymyoglobin and type I collagen containing ascorbic acid could successfully show autoxidation of oxymyoglobin in response to environmental temperature. The ultrathin nanofilms will be useful as oxygen-controlled releasable scaffolds for tissue engineering application. Temperature dependent controlled oxygen release from oxymyoglobin was achieved by modulating autoxidation of oxymyoglobin using ascorbic acid as a reductant.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc01545a