Factors associated with complicated pneumonia in children

Introduction Community acquired pneumonia (CAP) is a leading cause of morbidity in children, despite advances in health care and anti‐pneumococcal vaccine. Complicated pneumonia accounts for a significant burden with prolonged hospitalization. Finding risk factors for complicated pneumonia may help...

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Published in:Pediatric pulmonology 2021-08, Vol.56 (8), p.2700-2706
Main Authors: Masarweh, Kamal, Gur, Michal, Toukan, Yazeed, Bar‐Yoseph, Ronen, Kassis, Imad, Gut, Guy, Hakim, Fahed, Nir, Vered, Bentur, Lea
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Language:English
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community acquired pneumonia
complicated pneumonia
Hospitalization
MDClone
Pneumonia
Risk factors
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container_issue 8
container_start_page 2700
container_title Pediatric pulmonology
container_volume 56
creator Masarweh, Kamal
Gur, Michal
Toukan, Yazeed
Bar‐Yoseph, Ronen
Kassis, Imad
Gut, Guy
Hakim, Fahed
Nir, Vered
Bentur, Lea
description Introduction Community acquired pneumonia (CAP) is a leading cause of morbidity in children, despite advances in health care and anti‐pneumococcal vaccine. Complicated pneumonia accounts for a significant burden with prolonged hospitalization. Finding risk factors for complicated pneumonia may help in tailoring management. We aimed to identify risk factors for developing complicated pneumonia and need for intervention. Methods A retrospective single tertiary center study. Children admitted with a diagnosis of CAP and/or complicated pneumonia (parapneumonic effusion, empyema, necrotizing pneumonia, and lung abscess) on January 2001–March 2020 were included. Demographic, clinical, and laboratory parameters were collected using MDclone, a data acquisition tool. Risk factors for complicated pneumonia (on admission or during hospitalization) and risk for intervention were analyzed. Results A total of 6778 children with pneumonia were included; 323 arrived at the Emergency Department with complicated pneumonia while 232 developed a complication during hospitalization. Risk factors for complicated pneumonia (on admission or during hospitalization) were Arab ethnicity, cardiac disease, increased age, and CRP and low O2 Sat (OR = 2.236 p 
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Complicated pneumonia accounts for a significant burden with prolonged hospitalization. Finding risk factors for complicated pneumonia may help in tailoring management. We aimed to identify risk factors for developing complicated pneumonia and need for intervention. Methods A retrospective single tertiary center study. Children admitted with a diagnosis of CAP and/or complicated pneumonia (parapneumonic effusion, empyema, necrotizing pneumonia, and lung abscess) on January 2001–March 2020 were included. Demographic, clinical, and laboratory parameters were collected using MDclone, a data acquisition tool. Risk factors for complicated pneumonia (on admission or during hospitalization) and risk for intervention were analyzed. Results A total of 6778 children with pneumonia were included; 323 arrived at the Emergency Department with complicated pneumonia while 232 developed a complication during hospitalization. Risk factors for complicated pneumonia (on admission or during hospitalization) were Arab ethnicity, cardiac disease, increased age, and CRP and low O2 Sat (OR = 2.236 p &lt; .001, OR = 4.376 p &lt; .001, OR = 1.131 p &lt; .001, OR = 1.065 p &lt; .001 and OR = 0.959 p = .029, respectively). O2 Sat was lower, while fever and CRP were higher in patients with complicated pneumonia requiring intervention. Conclusions Identifying children at risk for complicated pneumonia may help in decision‐making in the Emergency Department and during hospitalization. The increased risk of the Arab population for complicated pneumonia requires further understanding. Addressing the underlying socioeconomic and ethnic health inequities may help to decrease the disease burden in this population.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.25468</identifier><identifier>PMID: 33991059</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>community acquired pneumonia ; complicated pneumonia ; Hospitalization ; MDClone ; Pneumonia ; Risk factors</subject><ispartof>Pediatric pulmonology, 2021-08, Vol.56 (8), p.2700-2706</ispartof><rights>2021 Wiley Periodicals LLC</rights><rights>This article is protected by copyright. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3578-c57e0859399d03c80c4240b8349ad5ffaf5bb198cd9b53c9f9d2033df13241af3</citedby><cites>FETCH-LOGICAL-c3578-c57e0859399d03c80c4240b8349ad5ffaf5bb198cd9b53c9f9d2033df13241af3</cites><orcidid>0000-0003-0310-1512 ; 0000-0001-7279-9294 ; 0000-0002-0055-5415 ; 0000-0002-9874-7617 ; 0000-0002-5347-1426</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33991059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Masarweh, Kamal</creatorcontrib><creatorcontrib>Gur, Michal</creatorcontrib><creatorcontrib>Toukan, Yazeed</creatorcontrib><creatorcontrib>Bar‐Yoseph, Ronen</creatorcontrib><creatorcontrib>Kassis, Imad</creatorcontrib><creatorcontrib>Gut, Guy</creatorcontrib><creatorcontrib>Hakim, Fahed</creatorcontrib><creatorcontrib>Nir, Vered</creatorcontrib><creatorcontrib>Bentur, Lea</creatorcontrib><title>Factors associated with complicated pneumonia in children</title><title>Pediatric pulmonology</title><addtitle>Pediatr Pulmonol</addtitle><description>Introduction Community acquired pneumonia (CAP) is a leading cause of morbidity in children, despite advances in health care and anti‐pneumococcal vaccine. Complicated pneumonia accounts for a significant burden with prolonged hospitalization. Finding risk factors for complicated pneumonia may help in tailoring management. We aimed to identify risk factors for developing complicated pneumonia and need for intervention. Methods A retrospective single tertiary center study. Children admitted with a diagnosis of CAP and/or complicated pneumonia (parapneumonic effusion, empyema, necrotizing pneumonia, and lung abscess) on January 2001–March 2020 were included. Demographic, clinical, and laboratory parameters were collected using MDclone, a data acquisition tool. Risk factors for complicated pneumonia (on admission or during hospitalization) and risk for intervention were analyzed. Results A total of 6778 children with pneumonia were included; 323 arrived at the Emergency Department with complicated pneumonia while 232 developed a complication during hospitalization. Risk factors for complicated pneumonia (on admission or during hospitalization) were Arab ethnicity, cardiac disease, increased age, and CRP and low O2 Sat (OR = 2.236 p &lt; .001, OR = 4.376 p &lt; .001, OR = 1.131 p &lt; .001, OR = 1.065 p &lt; .001 and OR = 0.959 p = .029, respectively). O2 Sat was lower, while fever and CRP were higher in patients with complicated pneumonia requiring intervention. Conclusions Identifying children at risk for complicated pneumonia may help in decision‐making in the Emergency Department and during hospitalization. The increased risk of the Arab population for complicated pneumonia requires further understanding. Addressing the underlying socioeconomic and ethnic health inequities may help to decrease the disease burden in this population.</description><subject>community acquired pneumonia</subject><subject>complicated pneumonia</subject><subject>Hospitalization</subject><subject>MDClone</subject><subject>Pneumonia</subject><subject>Risk factors</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp90E9LwzAYBvAgipvTix9ACl5E6Myfpk2OMpwKA3dw55AmKctom5qsjH17s3V68ODphbw_nrw8ANwiOEUQ4qeu6-spplnOzsAYQc5TmPH8HIxZQWmas5yMwFUIGwjjjqNLMCIkTkj5GPC5VFvnQyJDcMrKrdHJzm7XiXJNV1t1fOha0zeutTKxbaLWttbetNfgopJ1MDenOQGr-cvn7C1dfLy-z54XqSK0YKmihYGM8vijhkQxqDKcwZKRjEtNq0pWtCwRZ0rzkhLFK64xJERXiOAMyYpMwMOQ23n31ZuwFY0NytS1bI3rg8AUM1QwnNFI7__Qjet9G6-LihJGeIZRVI-DUt6F4E0lOm8b6fcCQXEoVBwKFcdCI747RfZlY_Qv_WkwAjSAna3N_p8osVyuFkPoN9bDf5k</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Masarweh, Kamal</creator><creator>Gur, Michal</creator><creator>Toukan, Yazeed</creator><creator>Bar‐Yoseph, Ronen</creator><creator>Kassis, Imad</creator><creator>Gut, Guy</creator><creator>Hakim, Fahed</creator><creator>Nir, Vered</creator><creator>Bentur, Lea</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0310-1512</orcidid><orcidid>https://orcid.org/0000-0001-7279-9294</orcidid><orcidid>https://orcid.org/0000-0002-0055-5415</orcidid><orcidid>https://orcid.org/0000-0002-9874-7617</orcidid><orcidid>https://orcid.org/0000-0002-5347-1426</orcidid></search><sort><creationdate>202108</creationdate><title>Factors associated with complicated pneumonia in children</title><author>Masarweh, Kamal ; Gur, Michal ; Toukan, Yazeed ; Bar‐Yoseph, Ronen ; Kassis, Imad ; Gut, Guy ; Hakim, Fahed ; Nir, Vered ; Bentur, Lea</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3578-c57e0859399d03c80c4240b8349ad5ffaf5bb198cd9b53c9f9d2033df13241af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>community acquired pneumonia</topic><topic>complicated pneumonia</topic><topic>Hospitalization</topic><topic>MDClone</topic><topic>Pneumonia</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Masarweh, Kamal</creatorcontrib><creatorcontrib>Gur, Michal</creatorcontrib><creatorcontrib>Toukan, Yazeed</creatorcontrib><creatorcontrib>Bar‐Yoseph, Ronen</creatorcontrib><creatorcontrib>Kassis, Imad</creatorcontrib><creatorcontrib>Gut, Guy</creatorcontrib><creatorcontrib>Hakim, Fahed</creatorcontrib><creatorcontrib>Nir, Vered</creatorcontrib><creatorcontrib>Bentur, Lea</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Masarweh, Kamal</au><au>Gur, Michal</au><au>Toukan, Yazeed</au><au>Bar‐Yoseph, Ronen</au><au>Kassis, Imad</au><au>Gut, Guy</au><au>Hakim, Fahed</au><au>Nir, Vered</au><au>Bentur, Lea</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors associated with complicated pneumonia in children</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr Pulmonol</addtitle><date>2021-08</date><risdate>2021</risdate><volume>56</volume><issue>8</issue><spage>2700</spage><epage>2706</epage><pages>2700-2706</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><abstract>Introduction Community acquired pneumonia (CAP) is a leading cause of morbidity in children, despite advances in health care and anti‐pneumococcal vaccine. Complicated pneumonia accounts for a significant burden with prolonged hospitalization. Finding risk factors for complicated pneumonia may help in tailoring management. We aimed to identify risk factors for developing complicated pneumonia and need for intervention. Methods A retrospective single tertiary center study. Children admitted with a diagnosis of CAP and/or complicated pneumonia (parapneumonic effusion, empyema, necrotizing pneumonia, and lung abscess) on January 2001–March 2020 were included. Demographic, clinical, and laboratory parameters were collected using MDclone, a data acquisition tool. Risk factors for complicated pneumonia (on admission or during hospitalization) and risk for intervention were analyzed. Results A total of 6778 children with pneumonia were included; 323 arrived at the Emergency Department with complicated pneumonia while 232 developed a complication during hospitalization. Risk factors for complicated pneumonia (on admission or during hospitalization) were Arab ethnicity, cardiac disease, increased age, and CRP and low O2 Sat (OR = 2.236 p &lt; .001, OR = 4.376 p &lt; .001, OR = 1.131 p &lt; .001, OR = 1.065 p &lt; .001 and OR = 0.959 p = .029, respectively). O2 Sat was lower, while fever and CRP were higher in patients with complicated pneumonia requiring intervention. Conclusions Identifying children at risk for complicated pneumonia may help in decision‐making in the Emergency Department and during hospitalization. The increased risk of the Arab population for complicated pneumonia requires further understanding. Addressing the underlying socioeconomic and ethnic health inequities may help to decrease the disease burden in this population.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33991059</pmid><doi>10.1002/ppul.25468</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0310-1512</orcidid><orcidid>https://orcid.org/0000-0001-7279-9294</orcidid><orcidid>https://orcid.org/0000-0002-0055-5415</orcidid><orcidid>https://orcid.org/0000-0002-9874-7617</orcidid><orcidid>https://orcid.org/0000-0002-5347-1426</orcidid></addata></record>
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subjects community acquired pneumonia
complicated pneumonia
Hospitalization
MDClone
Pneumonia
Risk factors
title Factors associated with complicated pneumonia in children
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