Limonoids isolated from the Fortunella crassifolia and the Citrus junos with their cell death-inducing activity on Adriamycin-treated cancer cell

From the fruits of Fortunella crassifolia and the peels of Citrus junos , two new limonoids, fortunellone and junosol were isolated together with three known compounds including nomilin. The chemical structures of the new compounds were elucidated based on chemical/physicochemical evidence. For fort...

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Bibliographic Details
Published in:Journal of natural medicines 2021-09, Vol.75 (4), p.998-1004
Main Authors: Kitagawa, Takahiro, Matsumoto, Takahiro, Imahori, Daisuke, Kobayashi, Mayuka, Okayama, Masaya, Ohta, Tomoe, Yoshida, Tatsusada, Watanabe, Tetsushi
Format: Article
Language:English
Subjects:
Absolute configuration
Biological products
Biomedical and Life Sciences
Biomedicine
Cell death
Cervical cancer
Cervix
Chemotherapy
Circular dichroism
Citrus junos
Complementary & Alternative Medicine
Flowers & plants
Fortunella crassifolia
Medicinal Chemistry
Pharmacology/Toxicology
Pharmacy
Plant Sciences
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Summary:From the fruits of Fortunella crassifolia and the peels of Citrus junos , two new limonoids, fortunellone and junosol were isolated together with three known compounds including nomilin. The chemical structures of the new compounds were elucidated based on chemical/physicochemical evidence. For fortunellone, the absolute configuration was established by comparison of experimental and predicted electronic circular dichroism (ECD) data. Fortunellon and nomilin significantly increased the number of dead cells on adriamycin (ADR)-treated human cervical cancer cells (HeLa). On the other hand, fortunellon and nomilin did not affects the number of dead cells alone. These results suggested that fortunellone and nomilin may have the potency as the chemotherapy enhancement agents. Graphic abstract
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-021-01528-8