Role of therapeutic apheresis in the treatment of pediatric kidney diseases

Therapeutic apheresis utilizes apheresis procedures in the treatment of a variety of conditions including kidney disease. Therapeutic plasma exchange (TPE) is the most common modality employed with the rationale of rapid reduction of a pathogenic substance distributed primarily in the intravascular...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2022-02, Vol.37 (2), p.315-328
Main Authors: Shah, Shweta, Joseph, Catherine, Srivaths, Poyyapakkam
Format: Article
Language:English
Subjects:
Apheresis
Blood Component Removal - adverse effects
Blood Component Removal - methods
Care and treatment
Child
Children
Complications and side effects
Diseases
Educational Review
Female
Humans
Kidney diseases
Kidney Diseases - therapy
Kidney transplantation
Male
Medicine
Medicine & Public Health
Methods
Nephrology
Pediatrics
Plasma Exchange - adverse effects
Plasma Exchange - methods
Registries
Urology
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Summary:Therapeutic apheresis utilizes apheresis procedures in the treatment of a variety of conditions including kidney disease. Therapeutic plasma exchange (TPE) is the most common modality employed with the rationale of rapid reduction of a pathogenic substance distributed primarily in the intravascular compartment; however other techniques which adsorb such pathogenic substances or alter the immune profile have been utilized in diseases affecting native and transplanted kidneys. This article discusses the modalities and technical details of therapeutic apheresis and summarizes its role in individual diseases affecting the kidney. Complications related to pediatric apheresis procedures and specifically related to apheresis in kidney disease are also discussed. Though therapeutic apheresis modalities are employed frequently in children with kidney disease, most experiences are extrapolated from adult studies. International and national registries need to be established to elucidate the role of apheresis modalities in children with kidney disease.
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-021-05093-w