Expression pattern of matrix metalloproteinases-2 and -9 and their tissue inhibitors in patients with chronic inflammatory demyelinating polyneuropathy

Background Matrix metalloproteinases (MMPs) are a heterogeneous family of endopeptidases that play a role in many physiological functions, including the immune response. An imbalance between the activity of MMPs and their physiological tissue inhibitors (TIMPs) has been proposed in the pathophysiolo...

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Bibliographic Details
Published in:Neurological sciences 2021-10, Vol.42 (10), p.4297-4300
Main Authors: Cosentino, Giuseppe, Di Stefano, Vincenzo, Presti, Rosalia Lo, Montana, Maria, Todisco, Massimiliano, Gastaldi, Matteo, Cortese, Andrea, Alfonsi, Enrico, Tassorelli, Cristina, Fierro, Brigida, Caimi, Gregorio, Brighina, Filippo
Format: Article
Language:English
Subjects:
Autoimmune diseases
Brief Communication
Demyelination
Enzyme-linked immunosorbent assay
Gelatinase A
Gelatinase B
Immune response
Inflammation
Matrix metalloproteinase
Medicine
Medicine & Public Health
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Patients
Physiology
Polyneuropathy
Psychiatry
Tissue inhibitor of metalloproteinase 1
Tissue inhibitor of metalloproteinase 2
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Summary:Background Matrix metalloproteinases (MMPs) are a heterogeneous family of endopeptidases that play a role in many physiological functions, including the immune response. An imbalance between the activity of MMPs and their physiological tissue inhibitors (TIMPs) has been proposed in the pathophysiology of different autoimmune disorders. We aimed to assess the plasmatic levels of MMP-2, MMP-9, and their inhibitors TIMP-1 and -2 in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Subjects and methods Twenty patients with CIDP and 20 age- and sex-matched healthy controls were enrolled. Plasma concentrations of MMP-2, MMP-9, TIMP-1, and TIMP-2 were determined by the enzyme-linked immunosorbent assay. Results CIDP subjects had higher MMP-9 concentrations along with TIMP-1 downregulation when compared to controls, with the consequent increase in the MMP-9/TIMP-1 ratio ( p
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-021-05314-y