The role of GSK3 in metabolic pathway perturbations in cancer

Malignant transformation and tumor progression are accompanied by significant perturbations in metabolic programs. As such, cancer cells support high ATP turnover to construct the building blocks needed to fuel neoplastic growth. The coordination of metabolic networks in malignant cells is dependent...

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Bibliographic Details
Published in:Biochimica et biophysica acta. Molecular cell research 2021-07, Vol.1868 (8), p.119059-119059, Article 119059
Main Authors: Papadopoli, David, Pollak, Michael, Topisirovic, Ivan
Format: Article
Language:English
Subjects:
AMPK
Cancer
GSK3
Metabolism
mTOR
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Summary:Malignant transformation and tumor progression are accompanied by significant perturbations in metabolic programs. As such, cancer cells support high ATP turnover to construct the building blocks needed to fuel neoplastic growth. The coordination of metabolic networks in malignant cells is dependent on the collaboration with cellular signaling pathways. Glycogen synthase kinase 3 (GSK3) lies at the convergence of several signaling axes, including the PI3K/AKT/mTOR, AMPK, and Wnt pathways, which influence cancer initiation, progression and therapeutic responses. Accordingly, GSK3 modulates metabolic processes, including protein and lipid synthesis, glucose and mitochondrial metabolism, as well as autophagy. In this review, we highlight current knowledge of the role of GSK3 in metabolic perturbations in cancer. •GSK3 lies at the intersection of PI3K/AKT/mTOR, AMPK, and Wnt pathways.•GSK3 modulates cellular metabolism, including catabolic and anabolic processes.•The metabolic reprogramming of cancer cells is influenced by the interplay between GSK3, AMPK, mTOR, and Wnt.
ISSN:0167-4889
1879-2596
DOI:10.1016/j.bbamcr.2021.119059