Disconnection of posterior part of the frontal aslant tract causes acute phase motor functional deficit

•We divided the right FAT into three segments according to anatomical structure.•Functional role of the right FAT was investigated by each segment in frontal gliomas.•Posterior FAT relates to acute-phase motor function.•However, damage of the right FAT may not cause permanent motor functional defici...

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Bibliographic Details
Published in:Brain and cognition 2021-07, Vol.151, p.105752-105752, Article 105752
Main Authors: Nakajima, Riho, Kinoshita, Masashi, Okita, Hirokazu, Shinohara, Harumichi, Nakada, Mitsutoshi
Format: Article
Language:English
Subjects:
brain tumor
Frontal aslant tract
Frontal gyrus
functional role
glioma
Prefrontal cortex
right frontal lobe
structural connectivity
Supplementary motor area
Surgery
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Summary:•We divided the right FAT into three segments according to anatomical structure.•Functional role of the right FAT was investigated by each segment in frontal gliomas.•Posterior FAT relates to acute-phase motor function.•However, damage of the right FAT may not cause permanent motor functional deficits. The frontal aslant tract (FAT) mainly connects the supplementary motor area (SMA) and inferior frontal gyrus. The left FAT is involved in language-related functions, while the functional role of the right FAT is not fully understood. The aim of this study was to investigate the function of the right FAT by dividing it into three segments according to the anatomical structure. A total of 34 right frontal gliomas who had undergone surgery were studied. Participants were assessed for the acute and chronic phases of several neuropsychological and motor functions. FAT was reconstructed into the anterior, middle, and posterior segments according to the cortical connections as the medial prefrontal cortex, pre-SMA, and SMA proper, respectively. The relationships between the damaged severity of each FAT segment and behavioral scores were analyzed. A significant relationship was observed only in the acute phase motor function and posterior segment of the FAT. The middle segment was involved in motor function, but it did not have a sufficient significance level compared to the posterior segment. Our study revealed that the right FAT can be divided into three segments and that its posterior segment is related to acute phase motor function.
ISSN:0278-2626
1090-2147
DOI:10.1016/j.bandc.2021.105752