Trinucleotide Cap Analogue Bearing a Locked Nucleic Acid Moiety: Synthesis, mRNA Modification, and Translation for Therapeutic Applications

The synthesis of a new trinucleotide cap analogue containing a locked nucleic acid (LNA) moiety such as m7(LNA)G­(5′)­ppp­(5′)­AmpG and its molecular biology applications are described. The most appealing feature is that this new cap analogue outperforms the standard trinucleotide cap m7G­(5′)­ppp­(...

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Bibliographic Details
Published in:Organic letters 2021-06, Vol.23 (11), p.4133-4136
Main Authors: Senthilvelan, Annamalai, Vonderfecht, Tyson, Shanmugasundaram, Muthian, Pal, Indra, Potter, Jason, Kore, Anilkumar R
Format: Article
Language:English
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Summary:The synthesis of a new trinucleotide cap analogue containing a locked nucleic acid (LNA) moiety such as m7(LNA)G­(5′)­ppp­(5′)­AmpG and its molecular biology applications are described. The most appealing feature is that this new cap analogue outperforms the standard trinucleotide cap m7G­(5′)­ppp­(5′)­AmpG and the anti-reverse cap analogue m2 7,3′‑O G­(5′)­ppp­(5′)­G by a factor of 5 in terms of translational efficiency.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c01037