Cytotoxic lanostane triterpenoids from the ethanol extract of Schisandra viridis

Three new lanostane triterpenoids, designated as 6-hydroxyl schiglausin A (1), 29-hydroxyl schiglausin D (2), and 6-hydroxyl schiglausin G (3), were isolated from the ethanol extract of the stems of Schisandra viridis. Structural elucidation of all the compounds were performed by spectral methods su...

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Bibliographic Details
Published in:Journal of asian natural products research 2022-04, Vol.24 (4), p.321-327
Main Authors: Wang, Hai-Ying, Wang, Xiao-Ling, Xu, Li-Qin, Liu, Jun
Format: Article
Language:English
Subjects:
Cell Line, Tumor
cytotoxicity
Ethanol
lanostane triterpenoids
Molecular Structure
Plant Extracts
Schisandra - chemistry
Schisandra viridis
Schisandraceae
Triterpenes - chemistry
Triterpenes - pharmacology
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Summary:Three new lanostane triterpenoids, designated as 6-hydroxyl schiglausin A (1), 29-hydroxyl schiglausin D (2), and 6-hydroxyl schiglausin G (3), were isolated from the ethanol extract of the stems of Schisandra viridis. Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D ( 1 H- 1 H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated compounds were tested in vitro for cytotoxic activities. As a result, compound 1 exhibited cytotoxic activities for all six tested human lung cancer cell lines with IC 50 values less than 10 μM.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2021.1918120