Plant-based vaccines and cancer therapy: Where are we now and where are we going?

Therapeutic vaccines are an effective approach in cancer therapy for treating the disease at later stages. The Food and Drug Administration (FDA) recently approved the first therapeutic cancer vaccine, and further studies are ongoing in clinical trials. These are expected to result in the future dev...

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Bibliographic Details
Published in:Pharmacological research 2021-07, Vol.169, p.105655-105655, Article 105655
Main Authors: Rahimian, Neda, Miraei, Hamid Reza, Amiri, Atefeh, Ebrahimi, Mohammad Saeid, Nahand, Javid Sadri, Tarrahimofrad, Hossein, Hamblin, Michael R., Khan, Haroon, Mirzaei, Hamed
Format: Article
Language:English
Subjects:
Animals
Cancer
Cancer Vaccines - therapeutic use
Humans
Neoplasms - therapy
Plant-based expression system
Plants, Genetically Modified - genetics
Recombinant proteins
Therapeutic vaccine
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Summary:Therapeutic vaccines are an effective approach in cancer therapy for treating the disease at later stages. The Food and Drug Administration (FDA) recently approved the first therapeutic cancer vaccine, and further studies are ongoing in clinical trials. These are expected to result in the future development of vaccines with relatively improved efficacy. Several vaccination approaches are being studied in pre-clinical and clinical trials, including the generation of anti-cancer vaccines by plant expression systems.This approach has advantages, such as high safety and low costs, especially for the synthesis of recombinant proteins. Nevertheless, the development of anti-cancer vaccines in plants is faced with some technical obstacles.Herein, we summarize some vaccines that have been used in cancer therapy, with an emphasis on plant-based vaccines. [Display omitted]
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2021.105655