A Review of Characteristics, Properties, Application of Nanocarriers and Analytical Methods of Luliconazole

Luliconazole is an imidazole agent, used for the treatment of fungi infection, especially dermatophytes. The mechanism of action of the drug consisting in inhibits sterol 14α-demethylase which interferes with ergosterol biosynthesis. Due to low aqueous solubility and highly lipophilic, there is a ne...

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Bibliographic Details
Published in:Critical reviews in analytical chemistry 2022-11, Vol.52 (8), p.1930-1937
Main Authors: dos Santos Porto, Douglas, Bajerski, Lisiane, Donadel Malesuik, Marcelo, Soldateli Paim, Clésio
Format: Article
Language:English
Subjects:
Analytical methods
Antifungal agents
Biosynthesis
Drug carriers
Drug delivery
Drug delivery systems
Ergosterol
Imidazole
Lipophilic
Liquid chromatography
luliconazole
Mathematical analysis
nanocarriers
Permeability
physicochemical properties
Raw materials
review
Reviews
Solubility
Spectrophotometry
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Summary:Luliconazole is an imidazole agent, used for the treatment of fungi infection, especially dermatophytes. The mechanism of action of the drug consisting in inhibits sterol 14α-demethylase which interferes with ergosterol biosynthesis. Due to low aqueous solubility and highly lipophilic, there is a need to develop drug delivery systems (nanocarriers) capable to increase the solubility, permeability, and skin retention of luliconazole, and promote a better therapeutic effect. In this context, this review presents characteristics, properties, nanocarriers, and analytical methods used for luliconazole. From the analyzed studies, the majority reports the use of RP-HPLC techniques for luliconazole determination, but also are cited spectrophotometric UV methods. The luliconazole has been qualitatively and quantitatively analyzed in different matrices, such as raw material and pharmaceutical formulations, however, in this review, only one study was found with the luliconazole quantification biological matrix, demonstrating the lack of studies related to the quantification of the drug in biological matrices. The drug quantification in different matrices by analytical methods is of great importance since they assist in the control of the quality, efficacy, and safety of the medicine.
ISSN:1040-8347
1547-6510
DOI:10.1080/10408347.2021.1926219