Potent Antihyperuricemic Triterpenoids Based on Two Unprecedented Scaffolds from the Leaves of Alstonia scholaris

Two rearranged triterpenoids, representing new subtypes of pentacyclic triterpenoids, with unique 6/6/6/7/5 and 6/6/5/6/6/6 ring systems were isolated from Alstonia scholaris. Their structures were established by spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichr...

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Bibliographic Details
Published in:Organic letters 2021-06, Vol.23 (11), p.4158-4162
Main Authors: Hu, Bin-Yuan, Zhao, Yun-Li, Xiong, Deng-Sen, He, Ying-Jie, Zhou, Zhong-Shun, Zhu, Pei-Feng, Wang, Zhao-Jie, Wang, Yong-Liang, Zhao, Li-Xing, Luo, Xiao-Dong
Format: Article
Language:English
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Summary:Two rearranged triterpenoids, representing new subtypes of pentacyclic triterpenoids, with unique 6/6/6/7/5 and 6/6/5/6/6/6 ring systems were isolated from Alstonia scholaris. Their structures were established by spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Both compounds exhibited potent antihyperuricemic bioactivity in vitro and in vivo.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c01102