Relationship between F-18 florbetapir uptake in occipital lobe and neurocognitive performance in Alzheimer’s disease

Purpose To determine the association between occipital amyloid-PET uptake and neurocognitive performance in Alzheimer’s disease (AD). Materials and methods Fifty-eight participants with normal aged, mild cognitive impairment (MCI) due to AD and AD subjects who underwent F-18 florbetapir brain PET/CT...

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Bibliographic Details
Published in:Japanese journal of radiology 2021-10, Vol.39 (10), p.984-993
Main Authors: Thientunyakit, Tanyaluck, Thongpraparn, Thonnapong, Sethanandha, Chakmeedaj, Yamada, Takahiro, Kimura, Yuichi, Muangpaisan, Weerasak, Ishii, Kazunari
Format: Article
Language:English
Subjects:
Alzheimer's disease
Cognition
Cognitive ability
Computed tomography
Cortex (parietal)
Fluorine isotopes
Imaging
Medicine
Medicine & Public Health
Neurodegenerative diseases
Nuclear Medicine
Occipital lobe
Original Article
Positron emission
Positron emission tomography
Radioisotopes
Radiology
Radiotherapy
Tomography
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Summary:Purpose To determine the association between occipital amyloid-PET uptake and neurocognitive performance in Alzheimer’s disease (AD). Materials and methods Fifty-eight participants with normal aged, mild cognitive impairment (MCI) due to AD and AD subjects who underwent F-18 florbetapir brain PET/CT scans were divided into four groups (A, normal; B, MCI; C, mild AD; and D, moderate/severe AD). Semiquantitative analyses of SUVR images were performed. The differences between groups and the correlations between florbetapir uptake and Thai Mental State Examination (TMSE) scores were determined. Significant differences were defined using a P  
ISSN:1867-1071
1867-108X
DOI:10.1007/s11604-021-01132-6