Treatment age and neurocognitive outcomes following proton beam radiotherapy for pediatric low‐ and intermediate‐grade gliomas

The relationship between age and neurocognitive functioning following proton beam radiotherapy (PRT) in low‐ and intermediate‐grade gliomas (LIGG) has yet to be examined. Eighteen LIGG patients treated with PRT were prospectively enrolled and received annual neurocognitive evaluations of perceptual/...

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Bibliographic Details
Published in:Pediatric blood & cancer 2021-08, Vol.68 (8), p.e29096-n/a
Main Authors: Heitzer, Andrew M., Kahalley, Lisa S., Minard, Charles G., Stafford, Claire, Grosshans, David R., Okcu, M. Fatih, Raghubar, Kimberly P., Gragert, Marsha, McCurdy, Mark, Warren, Emily H., Gomez, Jocelyn, Ris, M. Douglas, Paulino, Arnold C., Chintagumpala, Murali
Format: Article
Language:English
Subjects:
Adolescent
Age
Age Factors
Brain cancer
Brain Neoplasms - radiotherapy
Child
Child, Preschool
Cognition
Cognitive ability
Craniospinal Irradiation
Glioma
Glioma - radiotherapy
Hematology
Humans
Infant
Language
low‐grade glioma
Oncology
Patients
pediatric brain tumor
Pediatrics
proton radiotherapy
Proton Therapy
Radiation therapy
Short term memory
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Summary:The relationship between age and neurocognitive functioning following proton beam radiotherapy (PRT) in low‐ and intermediate‐grade gliomas (LIGG) has yet to be examined. Eighteen LIGG patients treated with PRT were prospectively enrolled and received annual neurocognitive evaluations of perceptual/verbal reasoning, working memory, and processing speed postradiotherapy. The median age at diagnosis was 8.2 years (range 1.0–14.7) and the median age at PRT was 9.9 years (range 4.2–17.0). Patients' neurocognitive performance did not change on any measure following PRT (p ≥ .142). We did not observe significant changes in cognitive function over time among a small group of LIGG patients treated with PRT.
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.29096