Value of chitinase-like protein YKL-40 in bronchoalveolar lavage fluid for predicting refractory Mycoplasma pneumoniae pneumonia in children

• Published in: Zhongguo dang dai er ke za zhi 2021-05, Vol.23 (5), p.471
• Main Authors: Huang, Li-Lin, Huang, Dong-Ping, Lu, Ling-Long, Li, Jing, Peng, Shu-Mei
• Format: Article
• Language: Chinese
• Subjects: Bronchoalveolar Lavage Fluid; Child; Chitinase-3-Like Protein 1; Chitinases; Humans; Mycoplasma pneumoniae; Pneumonia, Mycoplasma - diagnosis
• ISSN: 1008-8830
• DOI: 10.7499/j.issn.1008-8830.2012095

To evaluate the value of chitinase-like protein YKL-40 in bronchoalveolar lavage fluid (BALF) for predicting refractory pneumonia (RMPP) in children. A total of 50 children with common pneumonia (MPP) and 22 children with RMPP were enrolled. The two groups were compared in terms of clinical features, laboratory examination results, imaging findings, and YKL-40 levels in BALF. The receiver operating characteristic (ROC) curve was used to evaluate the value of YKL-40 in BALF for predicting RMPP. Compared with the common MPP group, the RMPP group had significantly higher incidence rates of fever, shortness of breath, lung consolidation, and pleural effusion ( < 0.05) and significantly higher serum levels of C-reactive protein and lactate dehydrogenase ( < 0.05). The RMPP group had a significantly higher level of YKL-40 in BALF than the common MPP group ( < 0.05). The ROC curve plotted based on the level of YKL-40 in BALF had an area under the ROC curve of 0.750, a sensitivity of 72.7% and a specificity of 64.0% for predicting RMPP. There is an increase in the level of YKL-40 in BALF in children with RMPP, and the level of YKL-40 in BALF has a certain value for predicting RMPP.