Aquagenic wrinkling in children under two years of age: Could this be a potential clinical referral tool for cystic fibrosis among non-screened populations?

•Delayed CF diagnosis worsens pulmonary and nutritional morbidity and mortality.•Palmar aquagenic wrinkling (AW) is seen in people with CF(PWCF) under 2 years.•Time to wrinkling (TTW) is lower in PWCF compared to carriers or healthy controls.•Higher IRT and sweat chloride levels were significantly a...

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Bibliographic Details
Published in:Journal of cystic fibrosis 2021-09, Vol.20 (5), p.e77-e83
Main Authors: Paul, Grace R., Bai, Shasha, Jackson, Kenneth, McCoy, Karen S.
Format: Article
Language:English
Subjects:
Aquagenic wrinkling
CF early diagnosis
Cystic Fibrosis - diagnosis
Female
Hand Dermatoses - etiology
Humans
Immersion
Infant
Infant, Newborn
Male
Mass Screening - methods
Nutrition
Referral and Consultation
Sweat - chemistry
Time Factors
Time to wrinkle
Water
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Summary:•Delayed CF diagnosis worsens pulmonary and nutritional morbidity and mortality.•Palmar aquagenic wrinkling (AW) is seen in people with CF(PWCF) under 2 years.•Time to wrinkling (TTW) is lower in PWCF compared to carriers or healthy controls.•Higher IRT and sweat chloride levels were significantly associated with lower TTW.•Global utility of AW as a referral tool to confirm CF needs further validation. Early diagnosis via newborn screening is crucial to improve clinical outcomes in patients with cystic fibrosis (CF). In resource-limited areas where newborn screening is unavailable and CF-related morbidity is high, clinical tools such as palmar aquagenic wrinkling (AW) have been considered. We report the utility of AW for possible early identification of CF in children
ISSN:1569-1993
1873-5010
DOI:10.1016/j.jcf.2021.04.002