Mesenchymal stem cells and extracellular vesicles for the treatment of pain: Current status and perspectives

Mesenchymal stem/stromal cells (MSCs) are multipotent progenitor cells of mesodermal origin. Due to their capacity for self‐renewal and differentiation into several cell types, MSCs have been extensively studied in experimental biology and regenerative medicine in recent years. Moreover, MSCs releas...

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Bibliographic Details
Published in:British journal of pharmacology 2022-09, Vol.179 (17), p.4281-4299
Main Authors: Bryk, Marta, Karnas, Elżbieta, Mlost, Jakub, Zuba‐Surma, Ewa, Starowicz, Katarzyna
Format: Article
Language:English
Subjects:
Analgesics
Angiogenesis
Apoptosis
Cell differentiation
Cell self-renewal
chronic pain
Experimental research
Extracellular vesicles
Immunomodulation
Inflammation
Mesenchymal stem cells
mesenchymal stromal/stem cells
Neuralgia
Osteoarthritis
pain
Paracrine signalling
Progenitor cells
Regenerative medicine
Spinal cord injuries
Stem cells
Stromal cells
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Summary:Mesenchymal stem/stromal cells (MSCs) are multipotent progenitor cells of mesodermal origin. Due to their capacity for self‐renewal and differentiation into several cell types, MSCs have been extensively studied in experimental biology and regenerative medicine in recent years. Moreover, MSCs release extracellular vesicles (EVs), which might be partly responsible for their regenerative properties. MSCs regulate several processes in target cells via paracrine signalling, such as immunomodulation, anti‐apoptotic signalling, tissue remodelling, angiogenesis and anti‐fibrotic signalling. The aim of this review is to provide a detailed description of the functional properties of MSCs and EVs and their potential clinical applications, with a special focus on pain treatment. The analgesic, anti‐inflammatory and regenerative properties of MSCs and EVs will be discussed for several diseases, such as neuropathic pain, osteoarthritis and spinal cord injury. LINKED ARTICLES This article is part of a themed issue on New discoveries and perspectives in mental and pain disorders. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.17/issuetoc
ISSN:0007-1188
1476-5381
DOI:10.1111/bph.15569