Complete remission of stage IV erythrodermic mycosis fungoides with large cell transformation through combination of pralatrexate and romidepsin followed by allogeneic hematopoietic stem cell transplantation

We report the case of a 59‐year‐old woman with stage IV erythrodermic mycosis fungoides (MF) and large cell transformation who, despite failing multiple previous treatments, achieved complete remission through a combination of pralatrexate and romidepsin followed by allogeneic hematopoietic stem cel...

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Bibliographic Details
Published in:Australasian journal of dermatology 2021-08, Vol.62 (3), p.e400-e403
Main Authors: Frederiks, Aaron J, Creeper, Katherine J, Spagnolo, Dominic V, Cannell, Paul, Radeski, Dejan
Format: Article
Language:English
Subjects:
allogeneic hematopoietic stem cell transplantation
Aminopterin - analogs & derivatives
Aminopterin - therapeutic use
Antibiotics, Antineoplastic - therapeutic use
Depsipeptides - therapeutic use
Female
Fungal infections
Hematopoietic Stem Cell Transplantation
Hematopoietic stem cells
Humans
large cell transformation
Lymphoma
Middle Aged
Mycosis
Mycosis fungoides
Mycosis Fungoides - pathology
Mycosis Fungoides - therapy
pralatrexate
Remission
Remission Induction
romidepsin
Skin Neoplasms - pathology
Skin Neoplasms - therapy
Stem cell transplantation
Treatment Outcome
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Summary:We report the case of a 59‐year‐old woman with stage IV erythrodermic mycosis fungoides (MF) and large cell transformation who, despite failing multiple previous treatments, achieved complete remission through a combination of pralatrexate and romidepsin followed by allogeneic hematopoietic stem cell transplantation (alloSCT). Further studies are needed in focussing on this combined regimen in treating cutaneous T‐cell lymphoma (CTCL) and its efficacy as a bridging regimen in facilitating successful alloSCT.
ISSN:0004-8380
1440-0960
DOI:10.1111/ajd.13606