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Early life factors and their relevance for markers of cardiometabolic risk in early adulthood
Early life exposures could be pertinent risk factors of cardiometabolic diseases in adulthood. We assessed the prospective associations of early life factors with markers of cardiometabolic risk among healthy German adults. We examined 348 term-born DONALD Study participants with measurement of fast...
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Published in: | Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2021-06, Vol.31 (7), p.2109-2121 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | Early life exposures could be pertinent risk factors of cardiometabolic diseases in adulthood. We assessed the prospective associations of early life factors with markers of cardiometabolic risk among healthy German adults.
We examined 348 term-born DONALD Study participants with measurement of fasting blood at the age of 18–24 years to assess metabolic indices: fatty liver index (FLI), hepatic steatosis index (HSI), pro-inflammatory score and insulin sensitivity (HOMA2-%S).
Early life factors (maternal weight in early pregnancy, maternal early pregnancy BMI, gestational weight gain (GWG), maternal age, birth weight and full breastfeeding (>17 weeks)) were assessed at enrolment of the offspring into the study. Multivariable linear regression models were used to analyze associations between early life factors and markers of cardiometabolic risk in early adulthood with adjustment for potential confounders.
A higher early pregnancy BMI was related to notably higher levels of offspring FLI, HSI, pro-inflammatory score and a lower HOMA2-%S (all p |
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ISSN: | 0939-4753 1590-3729 |
DOI: | 10.1016/j.numecd.2021.03.024 |